A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate (Q35998002)

11 August 2017

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate (English)

1 reference

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

11 August 2017

corrigendum / erratum

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Elizaveta Freinkman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Kıvanç Birsoy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Kyle R Brimacombe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Sze Ham Chan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Jason M Rohde

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Caroline A Lewis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Lotteke J Y M Swier

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Brian P Fiske

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Steve Cho

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Monther Abu-Remaileh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Yoav D Shaul

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Chieh Min Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Minerva Zhou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Min Jung Koh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Haeyoon Chung

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Shawn M Davidson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Amy Q Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Xin Xu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Li Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Ganesha Rai

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Kenneth D Westover

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Matthew G Vander Heiden

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Min Shen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Matthew B Boxer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

publication date

25 April 2016

1 reference

11 August 2017

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

452-458

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

NRF2 regulates serine biosynthesis in non-small cell lung cancer

4 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Quantitative flux analysis reveals folate-dependent NADPH production.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Genetic screens in human cells using the CRISPR-Cas9 system

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Serine, glycine and one-carbon units: cancer metabolism in full circle

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Cancer cell metabolism: one hallmark, many faces.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

DAD2 is an α/β hydrolase likely to be involved in the perception of the plant branching hormone, strigolactone

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Targeting cancer metabolism: a therapeutic window opens

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Compartmentalization of Mammalian folate-mediated one-carbon metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Highly parallel identification of essential genes in cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Detection of Mycoplasma in cell cultures.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Enzymic imbalance in serine metabolism in rat hepatomas

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rabbit liver in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Control analysis of mammalian serine biosynthesis. Feedback inhibition on the final step

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

isoMETLIN: a database for isotope-based metabolomics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Characterization of a dihydrolipoyl dehydrogenase having diaphorase activity of Clostridium kluyveri

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

Evidence for intracellular partitioning of serine and glycine metabolism in Chinese hamster ovary cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871733

23 September 2018

Identifiers

DOI

10.1038/NCHEMBIO.2070

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

27110680

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27110680%20AND%20SRC:MED&resulttype=core&format=json