The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. (Q35983641)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22044669%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation (English)

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15 January 2020

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15 January 2020

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15 January 2020

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15 January 2020

Claudia Nitsche

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15 January 2020

Paul J Grippo

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15 January 2020

Mouad Edderkaoui

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15 January 2020

Ryan M Moore

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15 January 2020

Guido Eibl

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15 January 2020

Noriyuki Kasahara

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15 January 2020

Janet Treger

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15 January 2020

language of work or name

English

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publication date

29 October 2011

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15 January 2020

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15 January 2020

volume

142

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15 January 2020

issue

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15 January 2020

page(s)

377-87.e1-5

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NADPH Oxidase Activation in Pancreatic Cancer Cells Is Mediated through Akt-dependent Up-regulation of p22

15 January 2020

cites work

1 reference

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2 October 2017

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Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

2 October 2017

1 reference

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Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo

2 October 2017

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2 October 2017

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Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis

2 October 2017

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The phosphatase PHLPP controls the cellular levels of protein kinase C

2 October 2017

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NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases

2 October 2017

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siRNA directed against TrkA sensitizes human pancreatic cancer cells to apoptosis induced by gemcitabine through an inactivation of PI3K/Akt-dependent pathway.

2 October 2017

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Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation

2 October 2017

1 reference

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

2 October 2017

1 reference

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Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells.

2 October 2017

1 reference

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Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase

2 October 2017

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

2 October 2017

1 reference

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4545256

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

2 October 2017

1 reference

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Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells

2 October 2017

1 reference

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Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

2 October 2017

1 reference

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AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2

2 October 2017

1 reference

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Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway

2 October 2017

1 reference

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The protein kinase B/Akt signalling pathway in human malignancy

2 October 2017

1 reference

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The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

2 October 2017

1 reference

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Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer

2 October 2017

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

2 October 2017

1 reference

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Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies

2 October 2017

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Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer.

27 July 2018

1 reference

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Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma

24 September 2018

1 reference

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Frequent activation of AKT2 kinase in human pancreatic carcinomas

24 September 2018

1 reference

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Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways

24 September 2018

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A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22044669

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22044669

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22044669

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1053/J.GASTRO.2011.10.026

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22044669%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22044669%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

22044669

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22044669%20AND%20SRC:MED&resulttype=core&format=json