Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity. (Q35968334)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22534096%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity (English)

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30 January 2020

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30 January 2020

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30 January 2020

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30 January 2020

Victoria Lewis

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30 January 2020

Steven J Collins

series ordinal

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30 January 2020

Colin L Masters

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30 January 2020

publication date

26 April 2012

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Molecular Neurodegeneration

30 January 2020

published in

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30 January 2020

volume

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page(s)

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describes a project that uses

30 January 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3355018/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cells

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Formation of native prions from minimal components in vitro

2 October 2017

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Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

2 October 2017

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2 October 2017

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2 October 2017

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Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease

2 October 2017

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Distinct molecular phenotypes in bovine prion diseases

2 October 2017

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Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis

2 October 2017

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2 October 2017

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Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice

2 October 2017

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2 October 2017

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Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

2 October 2017

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2 October 2017

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Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

2 October 2017

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Identification of candidate proteins binding to prion protein

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy.

2 October 2017

1 reference

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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

2 October 2017

1 reference

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Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

2 October 2017

1 reference

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Evidence of mitochondrial involvement in scrapie infection

2 October 2017

1 reference

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Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells

2 October 2017

1 reference

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Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture

2 October 2017

1 reference

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Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection

2 October 2017

1 reference

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Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay

11 July 2018

1 reference

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Evolution of a strain of CJD that induces BSE-like plaques

11 July 2018

1 reference

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Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355018

Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease

11 July 2018

1 reference

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An experimental examination of the scrapie agent in cell membrane mixtures. II. The association of scrapie activity with membrane fractions

11 July 2018

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Pathogenesis of scrapie: study of the temporal development of clinical symptoms, of infectivity titres and scrapie-associated fibrils in brains of hamsters infected intraperitoneally

11 July 2018

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Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

11 July 2018

1 reference

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The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis

11 July 2018

1 reference

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Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters

11 July 2018

1 reference

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Differential effects of prion particle size on infectivity in vivo and in vitro

11 July 2018

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Enzymatic detergent treatment protocol that reduces protease-resistant prion protein load and infectivity from surgical-steel monofilaments contaminated with a human-derived prion strain.

24 September 2018

1 reference

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Isolation and characterization of a proteinase K-sensitive PrPSc fraction.

24 September 2018

1 reference

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Extended period of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control

24 September 2018

1 reference

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Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles

24 September 2018

1 reference

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The metabolism of glycosaminoglycans is impaired in prion diseases

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355018

A simplified method for the preparation of detergent-free lipid rafts

24 September 2018

1 reference

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Breakage of PrP aggregates is essential for efficient autocatalytic propagation of misfolded prion protein

24 September 2018

1 reference

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Sonication of proteins causes formation of aggregates that resemble amyloid

24 September 2018

1 reference

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Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strain

24 September 2018

1 reference

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Two different scrapie prions isolated in Japanese sheep flocks

24 September 2018

1 reference

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RNA molecules stimulate prion protein conversion

24 September 2018

1 reference

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Small, highly structured RNAs participate in the conversion of human recombinant PrP(Sen) to PrP(Res) in vitro

24 September 2018

1 reference

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Cellular heparan sulfate participates in the metabolism of prions

24 September 2018

1 reference

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Molecular classification of sporadic Creutzfeldt-Jakob disease.

24 September 2018

1 reference

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Sporadic Creutzfeldt-Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain

24 September 2018

1 reference

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Strain-dependent differences in beta-sheet conformations of abnormal prion protein

24 September 2018

1 reference

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Biochemical typing of scrapie strains

24 September 2018

1 reference

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Further purification and characterization of scrapie prions

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355018

Scrapie prions aggregate to form amyloid-like birefringent rods

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355018

A protease-resistant protein is a structural component of the scrapie prion

24 September 2018

1 reference

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Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355018

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells

14 November 2018

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12 December 2020

BSE infectivity in the absence of detectable PrP(Sc) accumulation in the tongue and nasal mucosa of terminally diseased cattle

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12 December 2020

RNA and CuCl2 induced conformational changes of the recombinant ovine prion protein

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12 December 2020

Species-barrier-independent prion replication in apparently resistant species

1 reference

12 December 2020

Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

1 reference

12 December 2020

Sphingolipid Depletion Increases Formation of the Scrapie Prion Protein in Neuroblastoma Cells Infected with Prions

1 reference

12 December 2020

Strain characterization of natural sheep scrapie and comparison with BSE

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12 December 2020

Identifiers

DOI

10.1186/1750-1326-7-18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22534096%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

30 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22534096%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

22534096

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22534096%20AND%20SRC:MED&resulttype=core&format=json