The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses (Q35950241)

11 August 2017

The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses (English)

1 reference

11 August 2017

Yves Pommier

1 reference

11 August 2017

Jennifer A Seiler

1 reference

11 August 2017

Chiara Conti

series ordinal

1 reference

11 August 2017

Ali Syed

series ordinal

1 reference

11 August 2017

Mirit I Aladjem

series ordinal

1 reference

11 August 2017

language of work or name

English

0 references

publication date

21 May 2007

1 reference

Molecular and Cellular Biology

11 August 2017

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

11 August 2017

5806-5818

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1952133/fullTextXML

inferred from PubMed Central ID database lookup

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

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The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

2 October 2017

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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DNA topoisomerase-targeting antitumor drugs can be studied in yeast

2 October 2017

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Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.

2 October 2017

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Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Checkpoint regulation of replication dynamics in UV-irradiated human cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic cata

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

The human topoisomerase I damage response plays a role in apoptosis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Visualization of altered replication dynamics after DNA damage in human cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

DNA topoisomerase I-mediated nicking of circular duplex DNA.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952133

ATM and ATR check in on origins: a dynamic model for origin selection and activation

24 September 2018

1 reference

12 December 2020

Regulation of DNA-replication origins during cell-cycle progression

1 reference

12 December 2020

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system

1 reference

12 December 2020

1 reference

12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

12 December 2020

Targeting the molecular mechanism of DNA replication

1 reference

12 December 2020

UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines

1 reference

12 December 2020

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function

1 reference

12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

12 December 2020

Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?

1 reference

12 December 2020

Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus

1 reference

12 December 2020

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

1 reference

12 December 2020

The spatial position and replication timing of chromosomal domains are both established in early G1 phase

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.02278-06

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

17515603

1 reference