Hypoxia Induces Production of L-2-Hydroxyglutarate. (Q35925050)

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20 February 2020

title

Hypoxia Induces Production of L-2-Hydroxyglutarate (English)

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20 February 2020

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20 February 2020

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20 February 2020

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20 February 2020

Lydia W S Finley

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Craig B Thompson

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20 February 2020

Raymond G Dematteo

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20 February 2020

Sriram Venneti

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20 February 2020

Lydia W S Finley

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20 February 2020

Chao Lu

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20 February 2020

Alexander R Judkins

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20 February 2020

Ariën S Rustenburg

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20 February 2020

Patrick B Grinaway

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20 February 2020

publication date

23 July 2015

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20 February 2020

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volume

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issue

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page(s)

304-311

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A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair

20 February 2020

cites work

1 reference

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Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells

2 October 2017

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

2 October 2017

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L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.

2 October 2017

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MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

2 October 2017

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Hypoxia and metabolism in cancer

2 October 2017

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Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux

2 October 2017

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HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

2 October 2017

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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

2 October 2017

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Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas

2 October 2017

1 reference

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Metabolite damage and its repair or pre-emption

2 October 2017

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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

2 October 2017

1 reference

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Progress in understanding 2-hydroxyglutaric acidurias

2 October 2017

1 reference

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

2 October 2017

1 reference

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

Understanding the Warburg effect: the metabolic requirements of cell proliferation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

L-2-hydroxyglutaric aciduria, a defect of metabolite repair

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

L-2-hydroxyglutaric aciduria and brain malignant tumors: a predisposing condition?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527873

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

2 October 2017

1 reference

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Reduction of alpha gamma-diketo and alpha-keto acids catalyzed by muscle preparations and by crystalline lactic dehydrogenase.

2 October 2017

1 reference

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STEREOCHEMICAL COURSE OF THE ISOCITRATE LYASE REACTION

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26212717

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Reduction of alpha-ketoglutarate by homogeneous lactic dehydrogenase X of testicular tissue

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26212717

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2015.06.023

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20 February 2020

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20 February 2020

PubMed publication ID

26212717

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26212717%20AND%20SRC:MED&resulttype=core&format=json