Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL (Q35913910)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26109728%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL (English)

1 reference

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18 February 2020

1 reference

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18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26109728%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Rajnish Kumar

1 reference

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18 February 2020

Ruimin Pan

1 reference

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18 February 2020

Chitra Upadhyay

1 reference

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18 February 2020

Luzia Mayr

1 reference

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18 February 2020

Sandra Cohen

1 reference

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18 February 2020

Xiao-Hong Wang

1 reference

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18 February 2020

Preetha Balasubramanian

1 reference

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18 February 2020

Arthur Nádas

1 reference

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18 February 2020

Michael S Seaman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26109728%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Susan Zolla-Pazner

1 reference

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18 February 2020

Catarina E Hioe

1 reference

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18 February 2020

language of work or name

English

0 references

publication date

24 June 2015

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18 February 2020

1 reference

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18 February 2020

volume

1 reference

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18 February 2020

issue

1 reference

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18 February 2020

page(s)

9090-9102

1 reference

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A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site

18 February 2020

cites work

1 reference

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Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer

27 July 2018

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A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralization

27 July 2018

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

27 July 2018

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Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

27 July 2018

1 reference

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HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages

27 July 2018

1 reference

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Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure

27 July 2018

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Increasing the potency and breadth of an HIV antibody by using structure-based rational design

27 July 2018

1 reference

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A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

27 July 2018

1 reference

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Quantitative assessment of masking of neutralization epitopes in HIV-1.

27 July 2018

1 reference

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Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain Exchanged

27 July 2018

1 reference

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Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16.

27 July 2018

1 reference

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Conserved structural elements in the V3 crown of HIV-1 gp120

27 July 2018

1 reference

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Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes

27 July 2018

1 reference

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Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization

27 July 2018

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

27 July 2018

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27 July 2018

1 reference

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

27 July 2018

1 reference

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Cross-clade neutralizing antibodies against HIV-1 induced in rabbits by focusing the immune response on a neutralizing epitope.

27 July 2018

1 reference

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Neutralizing antibody responses to subtype B and C adjuvanted HIV envelope protein vaccination in rabbits

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner

27 July 2018

1 reference

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Coot: model-building tools for molecular graphics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D

27 July 2018

1 reference

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Generation of neutralizing human monoclonal antibodies against parvovirus B19 proteins

27 July 2018

1 reference

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

27 July 2018

1 reference

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A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

27 July 2018

1 reference

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Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

27 July 2018

1 reference

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Identification of a major co-receptor for primary isolates of HIV-1

27 July 2018

1 reference

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

27 July 2018

1 reference

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120. NIH-NIAID AIDS Vaccine Clinical Tria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Complete nucleotide sequences of functional clones of the AIDS virus

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells

27 July 2018

1 reference

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Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 envelope glycoprotein

27 July 2018

1 reference

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Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody

27 July 2018

1 reference

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High prevalence of antibodies to the gp120 V3 region principal neutralizing determinant of HIV-1MN in sera from Africa and the Americas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding

27 July 2018

1 reference

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Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses

27 July 2018

1 reference

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Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Distinct mechanisms regulate exposure of neutralizing epitopes in the V2 and V3 loops of HIV-1 envelope

24 September 2018

1 reference

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Progress in HIV-1 vaccine development.

24 September 2018

1 reference

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Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

24 September 2018

1 reference

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The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

24 September 2018

1 reference

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Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial

24 September 2018

1 reference

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Elicitation of broadly reactive antibodies against glycan-modulated neutralizing V3 epitopes of HIV-1 by immune complex vaccines.

24 September 2018

1 reference

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A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.

24 September 2018

1 reference

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Broad neutralization coverage of HIV by multiple highly potent antibodies

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

24 September 2018

1 reference

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Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Structure of Antibody F425-B4e8 in Complex with a V3 Peptide Reveals a New Binding Mode for HIV-1 Neutralization

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Autoreactivity in human IgG+ memory B cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Factors determining the breadth and potency of neutralization by V3-specific human monoclonal antibodies derived from subjects infected with clade A or clade B strains of human immunodeficiency virus type 1

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.

24 September 2018

1 reference

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Diversity considerations in HIV-1 vaccine selection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524078

Processing of X-ray diffraction data collected in oscillation mode

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26109728

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26109728

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antibodies to the HIV-1 V3 loop in serum from infected persons contribute a major proportion of immune effector functions including complement activation, antibody binding, and neutralization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26109728

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.01280-15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26109728%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26109728%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

26109728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26109728%20AND%20SRC:MED&resulttype=core&format=json