PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. (Q35915584)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7972081%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

title

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major (English)

1 reference

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30 August 2019

main subject

pteridine reductase 1

1 reference

GeneDB

5 February 2019

pteridine reductase 1

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pteridine reductase 1

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1 reference

1 reference

1 reference

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30 August 2019

1 reference

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30 August 2019

B Nare

1 reference

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30 August 2019

D Freedman

series ordinal

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30 August 2019

L Hardy

series ordinal

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30 August 2019

language of work or name

English

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publication date

1 November 1994

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Proceedings of the National Academy of Sciences of the United States of America

30 August 2019

published in

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30 August 2019

volume

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30 August 2019

issue

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30 August 2019

page(s)

11442-11446

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Plasticity in chromosome number and testing of essential genes in Leishmania by targeting

30 August 2019

cites work

1 reference

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Is dihydropteridine reductase an anomalous dihydrofolate reductase, a flavin-like enzyme, or a short-chain dehydrogenase?

27 July 2018

1 reference

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Biochemistry and regulation of folate and methotrexate transport in Leishmania major

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Multiple drug resistance and conservative amplification of the H region in Leishmania major

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Estimation of circular DNA size using gamma-irradiation and pulsed-field gel electrophoresis

27 July 2018

1 reference

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Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.

27 July 2018

1 reference

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Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor

27 July 2018

1 reference

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Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Use of T7 RNA polymerase to direct expression of cloned genes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Nutritional requirements of wild-type and folate transport-deficient Leishmania donovani for pterins and folates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Biopterin conversion to reduced folates by Leishmania donovani promastigotes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Double targeted gene replacement for creating null mutants

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

A novel antifolate resistance gene on the amplified H circle of Leishmania.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

A member of the aldoketo reductase family confers methotrexate resistance in Leishmania

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Evaluation of methods for estimating the dissociation constant of tight binding enzyme inhibitors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

The auto-oxidation of tetrahydrobiopterin

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45247

Dihydropteridine reductase and tetrahydropterin in Crithidia fasciculata cells

24 September 2018

1 reference

12 December 2020

Simultaneous transient expression assays of the trypanosomatid parasite Leishmania using beta-galactosidase and beta-glucuronidase as reporter enzymes

1 reference

12 December 2020

Two more independent selectable markers for stable transfection of Leishmania

1 reference

12 December 2020

Independent Requirements for ‘Crithidia Factor’ and Folk Acid in a Trypanosomid Flagellate

1 reference

12 December 2020

Presence and properties of dihydrofolate reductases within the genus Crithidia

1 reference

12 December 2020

Folylpolyglutamates in Leishmania major

1 reference

12 December 2020

A common ancestor for Candida tropicalis and dehydrogenases that synthesize antibiotics and steroids

1 reference

12 December 2020

Gene replacement in parasitic protozoa

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.91.24.11442

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7972081%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

0 references

1 reference

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30 August 2019

PubMed publication ID

7972081

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7972081%20AND%20SRC:MED&resulttype=core&format=json