Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1 (Q35909996)

11 August 2017

Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1 (English)

1 reference

11 August 2017

1 reference

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14 June 2020

Naotaka Sekiyama

1 reference

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14 June 2020

Evangelos Papadopoulos

1 reference

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14 June 2020

Ricard A Rodriguez-Mias

1 reference

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14 June 2020

Gerhard Wagner

1 reference

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14 June 2020

Mélissa Léger-Abraham

1 reference

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14 June 2020

language of work or name

English

0 references

publication date

13 July 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

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14 June 2020

volume

112

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14 June 2020

issue

1 reference

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14 June 2020

page(s)

E4036-45

1 reference

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Molecular architecture of 4E-BP translational inhibitors bound to eIF4E

14 June 2020

cites work

1 reference

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Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

11 July 2018

1 reference

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4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

11 July 2018

1 reference

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4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis

11 July 2018

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Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

11 July 2018

1 reference

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Casein kinase 1ε promotes cell proliferation by regulating mRNA translation

11 July 2018

1 reference

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Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1.

11 July 2018

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11 July 2018

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Tumor suppression by small molecule inhibitors of translation initiation.

11 July 2018

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Translation regulation as a therapeutic target in cancer

11 July 2018

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Crystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repression

11 July 2018

1 reference

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Anti-oncogenic potential of the eIF4E-binding proteins

11 July 2018

1 reference

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Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap scheduling

11 July 2018

1 reference

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The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS.

11 July 2018

1 reference

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

11 July 2018

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Translational control in cancer.

11 July 2018

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Poisson-gap sampling and forward maximum entropy reconstruction for enhancing the resolution and sensitivity of protein NMR data

11 July 2018

1 reference

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Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site

11 July 2018

1 reference

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Clustal W and Clustal X version 2.0

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Inference of macromolecular assemblies from crystalline state

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Solving structures of protein complexes by molecular replacement with Phaser

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods

11 July 2018

1 reference

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Software extensions to UCSF chimera for interactive visualization of large molecular assemblies

11 July 2018

1 reference

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Coot: model-building tools for molecular graphics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

11 July 2018

1 reference

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eIF-4E expression and its role in malignancies and metastases.

11 July 2018

1 reference

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eIF4E--from translation to transformation

11 July 2018

1 reference

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Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E

11 July 2018

1 reference

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PHENIX: building new software for automated crystallographic structure determination

11 July 2018

2 references

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11 July 2018

https://api.crossref.org/works/10.1073%2FPNAS.1512118112

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

21 January 2018

1 reference

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Electrostatics of nanosystems: application to microtubules and the ribosome

11 July 2018

1 reference

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

11 July 2018

1 reference

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Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

11 July 2018

1 reference

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The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

24 September 2018

1 reference

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A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522750

Importance of C-terminal flexible region of 4E-binding protein in binding with eukaryotic initiation factor 4E.

24 September 2018

1 reference

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Highly efficient expression and purification system of small-size protein domains in Escherichia coli for biochemical characterization.

24 September 2018

1 reference

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A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1.

24 September 2018

1 reference

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PROCHECK: a program to check the stereochemical quality of protein structures

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1512118112

Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G: comparison with eIF4E-binding protein

21 January 2018

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

High-level synthesis in Escherichia coli of functional cap-binding eukaryotic initiation factor eIF-4E and affinity purification using a simplified cap-analog resin

1 reference

12 December 2020

mRNA cap binding proteins: essential factors for initiating translation

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1512118112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26170285%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26170285%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

PubMed publication ID

26170285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26170285%20AND%20SRC:MED&resulttype=core&format=json