Adenovirus type 12 early region 1B 54K protein significantly extends the life span of normal mammalian cells in culture (Q35891411)

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5 November 2019

title

Adenovirus type 12 early region 1B 54K protein significantly extends the life span of normal mammalian cells in culture (English)

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5 November 2019

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P. H. Gallimore

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P. S. Lecane

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S. Roberts

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S. M. Rookes

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R. J. Grand

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J. Parkhill

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language of work or name

English

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publication date

1 September 1997

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5 November 2019

September 1997

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National Center for Biotechnology Information

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full work available at URL

11 November 2024

https://jvi.asm.org/content/jvi/71/9/6629.full.pdf

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http://jvi.asm.org/cgi/content/abstract/71/9/6629

11 November 2024

online access status

open access

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https://europepmc.org/articles/PMC191941

11 November 2024

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https://europepmc.org/articles/PMC191941?pdf=render

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https://journals.asm.org/doi/pdf/10.1128/jvi.71.9.6629-6640.1997

11 November 2024

1 reference

10.1128/JVI.71.9.6629-6640.1997

Crossref

DOI

https://api.crossref.org/works/10.1128/JVI.71.9.6629-6640.1997

11 November 2024

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5 November 2019

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page(s)

6629-6640

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

5 November 2019

cites work

1 reference

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The serial cultivation of human diploid cell strains

27 July 2018

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The CBP co-activator is a histone acetyltransferase

27 July 2018

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Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

27 July 2018

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Control of p53 expression by adenovirus 12 early region 1A and early region 1B 54K proteins

27 July 2018

1 reference

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Telomerase activation by the E6 gene product of human papillomavirus type 16.

27 July 2018

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Abnormal centrosome amplification in the absence of p53.

27 July 2018

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In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes

27 July 2018

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E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts

27 July 2018

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Unraveling the function of the retinoblastoma gene

27 July 2018

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Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

27 July 2018

1 reference

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Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells

27 July 2018

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Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

27 July 2018

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WAF1, a potential mediator of p53 tumor suppression

27 July 2018

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

27 July 2018

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Telomerase activity in human ovarian carcinoma

27 July 2018

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Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

27 July 2018

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Enhanced expression of p53 in human cells infected with mutant adenoviruses

27 July 2018

1 reference

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Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts

27 July 2018

1 reference

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Does telomere shortening drive selection for p53 mutation in human cancer?

27 July 2018

1 reference

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SV40-induced immortalization of human cells

27 July 2018

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The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression.

27 July 2018

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

27 July 2018

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Distinct modulation of p53 activity in transcription and cell-cycle regulation by the large (54 kDa) and small (21 kDa) adenovirus E1B proteins

27 July 2018

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

27 July 2018

1 reference

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Telomere elongation in immortal human cells without detectable telomerase activity

27 July 2018

1 reference

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Isolation and characterization of four adenovirus type 12-transformed human embryo kidney cell lines

27 July 2018

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Expression of region E1b of human adenoviruses in the absence of region E1a is not sufficient for complete transformation

27 July 2018

1 reference

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Cloning of DNA Fragments from the Left End of the Adenovirus Type 12 Genome: Transformation by Cloned Early Region 1

27 July 2018

1 reference

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Mechanisms of human cell neoplastic transformation: relationship of specific abnormal clone formation to prolonged lifespan in X-irradiated human diploid fibroblasts.

27 July 2018

1 reference

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Properties of rat cells transformed by DNA plasmids containing adenovirus type 12 E1 DNA or specific fragments of the E1 region: comparison of transforming frequencies

27 July 2018

1 reference

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Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production

27 July 2018

1 reference

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Human skin fibroblasts in vitro differentiate along a terminal cell lineage

27 July 2018

1 reference

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Transformation of human embryo retinoblasts with simian virus 40, adenovirus and ras oncogenes

27 July 2018

1 reference

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Differential transformation of primary human embryo retinal cells by adenovirus E1 regions and combinations of E1A + ras.

27 July 2018

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Host range mutants of adenovirus type 12 E1 defective for lytic infection, transformation, and oncogenicity.

27 July 2018

1 reference

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The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs

27 July 2018

1 reference

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Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells

27 July 2018

1 reference

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Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport

27 July 2018

1 reference

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Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

27 July 2018

1 reference

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Improved retroviral vectors for gene transfer and expression

27 July 2018

1 reference

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HPV-18 immortalization of human keratinocytes

27 July 2018

1 reference

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Characterization of primary human keratinocytes transformed by human papillomavirus type 18.

27 July 2018

1 reference

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Telomere reduction in human colorectal carcinoma and with ageing

27 July 2018

1 reference

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Telomeres shorten during ageing of human fibroblasts

27 July 2018

1 reference

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Replicative senescence: the human fibroblast comes of age.

27 July 2018

1 reference

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Rearrangement of the same chromosome regions in different SV40 transformed human skin keratinocyte lines is associated with tumourigenicity

27 July 2018

1 reference

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Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

27 July 2018

1 reference

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The use of beta-galactosidase fusion proteins encoding the early region 1 transforming proteins of adenovirus type 12 to examine the humoral response in tumour-bearing animals

27 July 2018

1 reference

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Telomere loss: mitotic clock or genetic time bomb?

27 July 2018

1 reference

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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191941

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

27 July 2018

1 reference

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Characteristics of a human cell line transformed by DNA from human adenovirus type 5

27 July 2018

1 reference

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Overexpression of wild-type p53 and c-Myc in human fetal cells transformed with adenovirus early region 1.

27 July 2018

1 reference

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Immortalization of normal human fibroblasts by treatment with 4-nitroquinoline 1-oxide.

24 September 2018

1 reference

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Assignment of SV40-immortalized cells to more than one complementation group for immortalization

24 September 2018

1 reference

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Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

24 September 2018

1 reference

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

24 September 2018

1 reference

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Telomere dynamics in an immortal human cell line

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191941

Relative difficulties in transforming human and animal cells in vitro.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191941

Limited and unlimited growth of sv40-transformed cells from human diploid mrc-5 fibroblasts

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191941

Malignant transformation of human embryo retinoblasts by cloned adenovirus 12 DNA

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191941

Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191941

Telomere end-replication problem and cell aging

24 September 2018

1 reference

12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

12 December 2020

SV40-INDUCED TRANSFORMATION OF HUMAN DIPLOID CELLS: CRISIS AND RECOVERY

1 reference

12 December 2020

Expression of the cellular p53 protein in cells transformed by adenovirus 12 and viral DNA fragments

1 reference

12 December 2020

Spontaneous establishment and characterization of mouse keratinocyte cell lines in serum-free medium

1 reference

12 December 2020

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1 reference

12 December 2020

The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

1 reference

12 December 2020

Telomere telomere recombination provides an express pathway for telomere acquisition

1 reference

12 December 2020

10.1128/JVI.71.9.6629-6640.1997

Identifiers

DOI

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9261385

11 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261385%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261385%20AND%20SRC:MED&resulttype=core&format=json