Mutational analysis of human T-cell leukemia virus type 2 Tax (Q35899345)

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7 November 2019

title

Mutational analysis of human T-cell leukemia virus type 2 Tax (English)

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7 November 2019

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T. M. Ross

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20 November 2024

A. C. Minella

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20 November 2024

Z. Y. Fang

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20 November 2024

S. M. Pettiford

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20 November 2024

P. L. Green

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20 November 2024

language of work or name

English

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publication date

1 November 1997

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7 November 2019

November 1997

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National Center for Biotechnology Information

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full work available at URL

20 November 2024

https://jvi.asm.org/content/jvi/71/11/8912.full.pdf

1 reference

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http://jvi.asm.org/cgi/content/abstract/71/11/8912

20 November 2024

online access status

open access

1 reference

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https://europepmc.org/articles/PMC192364

20 November 2024

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https://europepmc.org/articles/PMC192364?pdf=render

20 November 2024

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https://journals.asm.org/doi/pdf/10.1128/jvi.71.11.8912-8917.1997

20 November 2024

1 reference

10.1128/JVI.71.11.8912-8917.1997

Crossref

DOI

https://api.crossref.org/works/10.1128/JVI.71.11.8912-8917.1997

20 November 2024

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7 November 2019

volume

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7 November 2019

issue

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7 November 2019

page(s)

8912-8917

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The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes

7 November 2019

cites work

1 reference

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Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles

11 July 2018

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Genetic characterization of transactivation of the human T-cell leukemia virus type 1 promoter: Binding of Tax to Tax-responsive element 1 is mediated by the cyclic AMP-responsive members of the CREB/ATF family of transcription factors

11 July 2018

1 reference

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Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB

11 July 2018

1 reference

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HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs

11 July 2018

1 reference

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Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein.

11 July 2018

1 reference

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HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization

11 July 2018

1 reference

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Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB.

11 July 2018

1 reference

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Quantitative studies of the effect of HTLV-I Tax protein on CREB protein--DNA binding

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation.

11 July 2018

1 reference

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Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B

11 July 2018

1 reference

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Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Definition of a minimal activation domain in human T-cell leukemia virus type I Tax

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Chimeric proteins composed of Jun and CREB define domains required for interaction with the human T-cell leukemia virus type 1 Tax protein.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Structure of 3′ Terminal Region of Type II Human T Lymphotropic Virus: Evidence for New Coding Region

11 July 2018

1 reference

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Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells

11 July 2018

1 reference

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Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA

11 July 2018

1 reference

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Identification of the Putative Transforming Protein of the Human T-Cell Leukemia Viruses HTLV-I and HTLV-II

11 July 2018

1 reference

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Antigens Encoded by the 3′-Terminal Region of Human T-Cell Leukemia Virus: Evidence for a Functional Gene

11 July 2018

1 reference

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Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth

11 July 2018

1 reference

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Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator

11 July 2018

1 reference

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Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

11 July 2018

1 reference

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Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.

11 July 2018

1 reference

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The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.

11 July 2018

1 reference

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The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice

11 July 2018

1 reference

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c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I

11 July 2018

1 reference

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Identification of a cis-regulatory element involved in accumulation of human T-cell leukemia virus type II genomic mRNA.

11 July 2018

1 reference

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HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

11 July 2018

1 reference

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HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor.

11 July 2018

1 reference

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Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

In vitro mutagenesis of the human T-cell leukemia virus types I and II tax genes.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

The internal methionine codons of human T-cell leukemia virus type II rex gene are not required for p24rex production or virus replication and transformation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Induction of the HTLV-I LTR by Jun occurs through the Tax-responsive 21-bp elements

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Four regulatory elements in the human c-fos promoter mediate transactivation by HTLV-1 Tax protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Tax responsiveness of the GM-CSF promoter is mediated by mitogen-inducible sequences other than kappa B

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

HTLV-1 Tax has distinct but overlapping domains for transcriptional activation and for enhancer specificity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Characterization of a novel nuclear localization signal in the HTLV-I tax transactivator protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

NF-κB activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Phosphorylation regulates RNA binding by the human T-cell leukemia virus Rex protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

11 July 2018

1 reference

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Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Empirical Predictions of Protein Conformation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

Characterization of EBV-genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=192364

10.1128/JVI.71.11.8912-8917.1997

11 July 2018

Identifiers

DOI

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9343258

20 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9343258%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9343258%20AND%20SRC:MED&resulttype=core&format=json