Molecular and neuronal substrates for general anaesthetics (Q35868065)

10 August 2017

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title

Molecular and neuronal substrates for general anaesthetics (English)

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10 August 2017

Uwe Rudolph

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10 August 2017

Bernd Antkowiak

series ordinal

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10 August 2017

language of work or name

English

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publication date

1 September 2004

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Nature Reviews Neuroscience

10 August 2017

published in

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

709-720

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Intrinsic programmes of growth and survival in developing vertebrate neurons

10 August 2017

cites work

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Concepts and correlations relevant to general anaesthesia

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The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway

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Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane

21 January 2018

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Dose-dependent enhancement of in vivo GABA(A)-benzodiazepine receptor binding by isoflurane

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Quantitative EEG correlations with brain glucose metabolic rate during anesthesia in volunteers

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Dose-dependent effects of propofol on the central processing of thermal pain

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Wavelet analysis of middle latency auditory evoked responses: calculation of an index for detection of awareness during propofol administration

21 January 2018

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21 January 2018

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Pontine cholinergic mechanisms modulate the cortical electroencephalographic spindles of halothane anesthesia

21 January 2018

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Acetylcholine in mind: a neurotransmitter correlate of consciousness?

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Recovery from sleep deprivation occurs during propofol anesthesia

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Anesthesia, neural information processing, and conscious awareness

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Consciousness unbound: toward a paradigm of general anesthesia

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Invariant reversible QEEG effects of anesthetics

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The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro.

21 January 2018

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Different actions of general anesthetics on the firing patterns of neocortical neurons mediated by the GABA(A) receptor

21 January 2018

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Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography

21 January 2018

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Sequential effects of propofol on functional brain activation induced by auditory language processing: an event-related functional magnetic resonance imaging study

21 January 2018

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Subanesthetic isoflurane affects task-induced brain activation in a highly specific manner: a functional magnetic resonance imaging study

21 January 2018

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Functional imaging of the monkey brain

21 January 2018

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Dynamic properties of neurons in cortical area MT in alert and anaesthetized macaque monkeys.

21 January 2018

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Suppression of spinal cord motoneuron excitability correlates with surgical immobility during isoflurane anesthesia

21 January 2018

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Isoflurane action in the spinal cord blunts electroencephalographic and thalamic-reticular formation responses to noxious stimulation in goats

21 January 2018

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Peri-MAC Depression of a Nociceptive Withdrawal Reflex Is Accompanied by Reduced Dorsal Horn Activity with Halothane but not Isoflurane

21 January 2018

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Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane

21 January 2018

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Anesthetics and ion channels: molecular models and sites of action

21 January 2018

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Anesthetic-sensitive 2P domain K+ channels.

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Which GABAA-receptor subtypes really occur in the brain?

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Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics

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Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.

21 January 2018

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Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor

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Enflurane actions on spinal cords from mice that lack the beta3 subunit of the GABA(A) receptor

21 January 2018

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Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

21 January 2018

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The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

21 January 2018

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Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors.

21 January 2018

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Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2

21 January 2018

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2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels

21 January 2018

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Specific GABAA circuits for visual cortical plasticity.

21 January 2018

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Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

21 January 2018

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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

21 January 2018

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Molecular and neuronal substrate for the selective attenuation of anxiety.

21 January 2018

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Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

21 January 2018

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GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.

21 January 2018

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GABA(A) alpha 1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment

21 January 2018

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Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations

21 January 2018

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Therapy of Cushing's syndrome with steroid biosynthesis inhibitors

21 January 2018

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Activation of α2B-Adrenoceptors Mediates the Cardiovascular Effects of Etomidate

21 January 2018

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Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

21 January 2018

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The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599.

21 January 2018

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Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations

21 January 2018

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Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol

21 January 2018

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Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors

21 January 2018

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Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials

21 January 2018

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General anaesthetic actions on ligand-gated ion channels

21 January 2018

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Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice

21 January 2018

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Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol

21 January 2018

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Nitrous oxide-induced enhancement of gamma-aminobutyric acidA-mediated chloride currents in acutely dissociated hippocampal neurons

21 January 2018

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Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

21 January 2018

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Current assessment of targets and theories of anaesthesia

21 January 2018

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Claude Bernard and Anesthesia

21 January 2018

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Zur Theorie der Alkoholnarkose

31 March 2020

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Do general anaesthetics act by competitive binding to specific receptors?

31 March 2020

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Molecular mechanisms of general anaesthesia

31 March 2020

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Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis

31 March 2020

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Where do general anaesthetics act?

31 March 2020

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Anesthetic cutoff in cycloalkanemethanols. A test of current theories.

31 March 2020

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Arousal: revisiting the reticular activating system

31 March 2020

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Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography study

31 March 2020

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The divergent actions of volatile anaesthetics on background neuronal activity and reactive capability in the central nervous system in cats

31 March 2020

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Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans

31 March 2020

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Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex

31 March 2020

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Mid-latency auditory evoked potentials during ketamine anaesthesia in humans.

31 March 2020

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A Comparison of Psychologic Responses to Ketamine and Thiopental–Nitrous Oxide–Halothane Anesthesia

31 March 2020

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Visual Feature Integration and the Temporal Correlation Hypothesis

31 March 2020

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Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats

31 March 2020

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Anesthetic potency is not altered after hypothermic spinal cord transection in rats.

31 March 2020

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Exaggerated anesthetic requirements in the preferentially anesthetized brain.

31 March 2020

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The septohippocampal system participates in general anesthesia.

31 March 2020

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A comparative study of halothane and halopropane anesthesia including method for determining equipotency.

31 March 2020

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General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

31 March 2020

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Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

31 March 2020

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The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

31 March 2020

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The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum.

31 March 2020

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GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits

31 March 2020

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Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

31 March 2020

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Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue

31 March 2020

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Molecular targets for the myorelaxant action of diazepam.

31 March 2020

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Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice.

31 March 2020

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Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor

31 March 2020

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The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study.

31 March 2020

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Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats.

31 March 2020

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Nitrous oxide and xenon increase the efficacy of GABA at recombinant mammalian GABA(A) receptors

31 March 2020

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Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures

31 March 2020

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Propofol and sevoflurane in subanesthetic concentrations act preferentially on the spinal cord: evidence from multimodal electrophysiological assessment

31 March 2020

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Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN1496

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Dimensions Publication ID

10 August 2017

1031711883

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