Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease (Q35811072)

10 August 2017

Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease (English)

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10 August 2017

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Roland Matsouaka

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Tara L Spires-Jones

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Bradley T Hyman

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10 August 2017

Rebecca A Betensky

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10 August 2017

Eloise Hudry

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10 August 2017

Tadafumi Hashimoto

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10 August 2017

Michal Arbel-Ornath

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10 August 2017

Brian J Bacskai

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10 August 2017

Zhanyun Fan

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10 August 2017

Hai-Yan Wu

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10 August 2017

language of work or name

English

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publication date

1 February 2012

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10 August 2017

Journal of Neuroscience

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10 August 2017

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10 August 2017

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10 August 2017

3176-3192

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describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3296329/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models

11 July 2018

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11 July 2018

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Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

11 July 2018

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Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

11 July 2018

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Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling.

11 July 2018

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A calcineurin/AKAP complex is required for NMDA receptor–dependent long-term depression

11 July 2018

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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

11 July 2018

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Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

11 July 2018

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Amyloid deposition is associated with impaired default network function in older persons without dementia

11 July 2018

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Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

11 July 2018

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Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

11 July 2018

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A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors

11 July 2018

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Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition

11 July 2018

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The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.

11 July 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

11 July 2018

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Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images

11 July 2018

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Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS

11 July 2018

1 reference

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NFAT signaling in neural development and axon growth

11 July 2018

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Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice

11 July 2018

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NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

11 July 2018

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

11 July 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

11 July 2018

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Neurological complications in kidney transplant recipients.

11 July 2018

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Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

11 July 2018

1 reference

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Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models

11 July 2018

1 reference

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Transient and persistent dendritic spines in the neocortex in vivo

11 July 2018

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Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses

11 July 2018

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The transcription factor NFAT3 mediates neuronal survival

11 July 2018

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

11 July 2018

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Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

11 July 2018

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Calcineurin regulation of neuronal plasticity

11 July 2018

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Endogenous protein inhibitors of calcineurin

11 July 2018

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Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons

11 July 2018

1 reference

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Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar

11 July 2018

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Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360.

11 July 2018

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Imaging amyloid-beta deposits in vivo

11 July 2018

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NFAT signaling: choreographing the social lives of cells

11 July 2018

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

11 July 2018

1 reference

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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

11 July 2018

1 reference

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Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices

24 September 2018

1 reference

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Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

NFATc3 regulates Kv2.1 expression in arterial smooth muscle

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Messenger RNA and protein expression analysis of voltage-gated potassium channels in the brain of Abeta(25-35)-treated rats

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Comparative study of the distribution of calmodulin kinase II and calcineurin in the mouse brain

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Influence of potassium channel modulators on cognitive processes in mice.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296329

Nuclear calmodulin-binding proteins in rat neurons

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22378890

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.6439-11.2012

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

22378890

1 reference