Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). (Q35814421)

From Wikidata

Jump to navigation Jump to search

scientific article published on 24 February 2012

Language	Label	Description	Also known as
English	Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).	scientific article published on 24 February 2012

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2) (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

Plasmodium falciparum

0 references

Chandrakala Pidathala

1

object named as

Chandrakala Pidathala

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Richard K Amewu

2

object named as

Richard Amewu

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Bénédicte Pacorel

3

object named as

Bénédicte Pacorel

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

7

object named as

Suet C Leung

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

10

object named as

Paul A Stocks

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

12

object named as

Alison E Shone

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Sitthivut Charoensutthivarakul

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

15

object named as

Olivier Berger

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Alison Mbekeani

16

object named as

Alison Mbekeani

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Ashley J Warman

19

object named as

Ashley J Warman

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Giancarlo Biagini

20

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

21

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Peter Gibbons

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

W David Hong

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Raman Sharma

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Abhishek Srivastava

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Lee Taylor

14

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Alasdair Hill

17

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Nicholas E Fisher

18

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Paul M O'Neill

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

0 references

publication date

24 February 2012

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

55

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1831-1843

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Lipophilicity in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

The state of the art in anti-malarial drug discovery and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

A research agenda for malaria eradication: drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Extended-connectivity fingerprints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Current trends in ligand-based virtual screening: molecular representations, data mining methods, new application areas, and performance evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Type II NADH dehydrogenase inhibitor 1-hydroxy-2-dodecyl-4(1H)quinolone leads to collapse of mitochondrial inner-membrane potential and ATP depletion in Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Physiochemical drug properties associated with in vivo toxicological outcomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Similarity-based virtual screening using 2D fingerprints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

PowerMV: a software environment for molecular viewing, descriptor generation, data analysis and hit evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Antimalarial drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Reoptimization of MDL keys for use in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Molecular properties that influence the oral bioavailability of drug candidates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

The past, present and future of childhood malaria mortality in Africa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Human malaria parasites in continuous culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

11 July 2018

Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

24 September 2018

Semisynthesis and antiplasmodial activity of the quinoline alkaloid aurachin E.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

24 September 2018

Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297363

24 September 2018

Potent antimalarial 4-pyridones with improved physico-chemical properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/22364416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of a set of simple, interpretable ADMET rules of thumb

1 reference

https://pubmed.ncbi.nlm.nih.gov/22364416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the ubiquinol oxidation sites in cytochromes bo and bd from Escherichia coli using aurachin C analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/22364416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22364416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM201179H

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22364416%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35814421&oldid=2227834024"