CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients (Q35801549)

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scientific article published on 29 June 2015

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English	CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients	scientific article published on 29 June 2015

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

Europe PubMed Central

CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

0 references

2

object named as

Vikram Mehraj

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Jean-Pierre Routy

6

object named as

Jean-Pierre Routy

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

author name string

Wei Lu

1

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Europe PubMed Central

PMC publication ID

10 August 2017

Kishanda Vyboh

3

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Europe PubMed Central

PMC publication ID

10 August 2017

Wei Cao

4

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Europe PubMed Central

PMC publication ID

10 August 2017

Taisheng Li

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

publication date

29 June 2015

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Journal of the International AIDS Society

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Europe PubMed Central

PMC publication ID

10 August 2017

18

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Europe PubMed Central

PMC publication ID

10 August 2017

20052

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486418

27 July 2018

HIV and the gut microbiota, partners in crime: breaking the vicious cycle to unearth new therapeutic targets.

1 reference

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Immune Suppression by Myeloid Cells in HIV Infection: New Targets for Immunotherapy

1 reference

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27 July 2018

Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection

1 reference

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27 July 2018

Differential Reduction in Monocyte Activation and Vascular Inflammation With Integrase Inhibitor-Based Initial Antiretroviral Therapy Among HIV-Infected Individuals

1 reference

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27 July 2018

Course and Clinical Significance of CD8+ T-Cell Counts in a Large Cohort of HIV-Infected Individuals

1 reference

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27 July 2018

CD4/CD8 ratio is not predictive of multi-morbidity prevalence in HIV-infected patients but identify patients with higher CVD risk

1 reference

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27 July 2018

Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infection

1 reference

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CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells

1 reference

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Immunologic strategies for HIV-1 remission and eradication

1 reference

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CD8 T cell persistence in treated HIV infection

1 reference

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Aging of the human innate immune system in HIV infection

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HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality

1 reference

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Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsets

1 reference

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Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment

1 reference

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Delay in cART initiation results in persistent immune dysregulation and poor recovery of T-cell phenotype despite a decade of successful HIV suppression.

1 reference

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27 July 2018

Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.

1 reference

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Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration

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27 July 2018

Multiparametric bioinformatics distinguish the CD4/CD8 ratio as a suitable laboratory predictor of combined T cell pathogenesis in HIV infection

1 reference

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Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease

1 reference

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HIV-1 persistence in CD4+ T cells with stem cell-like properties

1 reference

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27 July 2018

Predictors of CD4:CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy

1 reference

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27 July 2018

Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers

1 reference

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27 July 2018

The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

1 reference

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Towards an HIV cure: a global scientific strategy

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Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions

1 reference

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27 July 2018

Factors influencing the normalization of CD4+ T-cell count, percentage and CD4+/CD8+ T-cell ratio in HIV-infected patients on long-term suppressive antiretroviral therapy

1 reference

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Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells

1 reference

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A challenge for the future: aging and HIV infection

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Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease

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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

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Effect of early versus deferred antiretroviral therapy for HIV on survival

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Hodgkin lymphoma in the Swiss HIV Cohort Study

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Immune activation and inflammation in HIV-1 infection: causes and consequences

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No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

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Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

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CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study

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HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

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CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use.

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Chronic inflammation in a long-term cohort of HIV-infected patients according to the normalization of the CD4:CD8 ratio.

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Immune control of HIV-1 reservoirs

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1 reference

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The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression

1 reference

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25 September 2018

CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy.

1 reference

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Impact of individual antiretroviral drugs on the risk of myocardial infarction in human immunodeficiency virus-infected patients: a case-control study nested within the French Hospital Database on HIV ANRS cohort CO4.

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Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy

1 reference

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Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of

1 reference

https://pubmed.ncbi.nlm.nih.gov/26130226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low CD4/CD8 T lymphocyte ratio in acute myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/26130226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Medical treatment of juvenile idiopathic arthritis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/26130226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population

1 reference

https://pubmed.ncbi.nlm.nih.gov/26130226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26130226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.7448/IAS.18.1.20052

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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