Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies (Q35786784)

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scientific article published on 26 June 2015

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English	Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies	scientific article published on 26 June 2015

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scholarly article

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18 February 2020

Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies (English)

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18 February 2020

neuropathic pain

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6

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18 February 2020

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Uma Anand

1

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18 February 2020

Yiangos Yiangou

2

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18 February 2020

Marco Sinisi

3

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18 February 2020

Michael Fox

4

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18 February 2020

Anthony MacQuillan

5

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18 February 2020

Yuri E Korchev

7

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18 February 2020

Chas Bountra

8

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18 February 2020

Tom McCarthy

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18 February 2020

Praveen Anand

10

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18 February 2020

publication date

26 June 2015

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18 February 2020

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18 February 2020

11

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18 February 2020

38

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18 February 2020

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Angiotensin II receptor type 2 activation is required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Angiotensinergic innervation of the kidney: Localization and relationship with catecholaminergic postganglionic and sensory nerve fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Intraneuronal angiotensinergic system in rat and human dorsal root ganglia

1 reference

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27 July 2018

Development of selective non-peptide angiotensin II type 2 receptor agonists

1 reference

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27 July 2018

The past, present and future of angiotensin II type 2 receptor stimulation

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27 July 2018

Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

MAP kinase and pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensin system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Role of tyrosine kinase receptors in angiotensin II AT2 receptor signaling: involvement in neurite outgrowth and in p42/p44mapk activation in NG108-15 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observations to mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

The brain renin-angiotensin system: location and physiological roles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Interactions between angiotensin-(1-7), kinins, and angiotensin II in kidney and blood vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

27 July 2018

Angiotensin-(1-7): an update.

1 reference

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27 July 2018

Franz Volhard Lecture. Renin-angiotensin system: a dual tissue and hormonal system for cardiovascular control

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27 July 2018

Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

The angiotensin II type 2 receptor for pain control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

Trophic factor and hormonal regulation of neurite outgrowth in sensory neuron-like 50B11 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

Cross-talk between inflammation and angiotensin II: studies based on direct transfection of cardiomyocytes with AT1R and AT2R cDNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

Angiotensin II and vascular inflammation.

1 reference

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25 September 2018

cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation

1 reference

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25 September 2018

Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482278

25 September 2018

Angiotensin-(1-7) downregulates the angiotensin II type 1 receptor in vascular smooth muscle cells

1 reference

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25 September 2018

Counterregulatory Actions of Angiotensin-(1-7)

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25 September 2018

Angiotensin II type 2 receptor-mediated regulation of rat neuronal K+ channels

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25 September 2018

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity.

1 reference

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25 September 2018

An alternative strategy for the radioimmunoassay of angiotensin peptides using amino-terminal-directed antisera: measurement of eight angiotensin peptides in human plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26111701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor (NGF) differentially regulates the chemosensitivity of adult rat cultured sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/26111701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26111701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor in the synovial fluid of patients with chronic arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26111701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1186/S12990-015-0038-X

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18 February 2020

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18 February 2020

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18 February 2020

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