Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease (Q35763138)

10 August 2017

title

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease (English)

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10 August 2017

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Ann C McKee

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10 August 2017

Sudad Saman

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10 August 2017

WonHee Kim

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10 August 2017

Mario Raya

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10 August 2017

Yvonne Visnick

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10 August 2017

Suhad Miro

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10 August 2017

Sarmad Saman

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10 August 2017

Bruce Jackson

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10 August 2017

Victor E Alvarez

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10 August 2017

Norman C Y Lee

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10 August 2017

Garth F Hall

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10 August 2017

language of work or name

English

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publication date

4 November 2011

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Journal of Biological Chemistry

10 August 2017

published in

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10 August 2017

volume

287

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10 August 2017

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10 August 2017

page(s)

3842-3849

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Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

10 August 2017

cites work

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2 October 2017

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2 October 2017

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2 October 2017

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CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy

2 October 2017

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Prion-like disorders: blurring the divide between transmissibility and infectivity

2 October 2017

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Interneuronal transfer of human tau between Lamprey central neurons in situ

2 October 2017

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ExoCarta: A compendium of exosomal proteins and RNA

2 October 2017

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The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid

2 October 2017

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Transmission and spreading of tauopathy in transgenic mouse brain

2 October 2017

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Exosomes: proteomic insights and diagnostic potential

2 October 2017

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Propagation of tau misfolding from the outside to the inside of a cell.

2 October 2017

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2 October 2017

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Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration

2 October 2017

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

2 October 2017

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Tyrosine phosphorylation-dependence of caveolae-mediated endocytosis

2 October 2017

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Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes

2 October 2017

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Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

2 October 2017

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Extracellular tau is toxic to neuronal cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Assembly of filamentous tau aggregates in human neuronal cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Tau phosphorylation: physiological and pathological consequences

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Cells release prions in association with exosomes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Tau interacts with src-family non-receptor tyrosine kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Neuropathological stageing of Alzheimer-related changes

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

A protein factor essential for microtubule assembly

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Secretion of human tau fragments resembling CSF-tau in Alzheimer's disease is modulated by the presence of the exon 2 insert.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Pattern of Tau forms in CSF is altered in progressive supranuclear palsy.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study Group.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

No increase in cerebrospinal fluid tau protein levels in patients with vascular dementia.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281682

Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22057275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22057275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neurofibrillary degeneration can be arrested in an in vivo cellular model of human tauopathy by application of a compound which inhibits tau filament formation in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22057275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.277061

1 reference

10 August 2017

1 reference

10 August 2017

1 reference