Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells (Q35749321)

10 August 2017

title

Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells (English)

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10 August 2017

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Barbara A Gilchrest

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10 August 2017

Mina Yaar

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10 August 2017

Mark S Eller

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10 August 2017

Izabela Panova

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10 August 2017

John Kubera

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10 August 2017

Lee Hng Wee

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10 August 2017

Kenneth H Cowan

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10 August 2017

language of work or name

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1 January 2007

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10 August 2017

published in

Breast Cancer Research

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

R13

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Features that determine telomere homolog oligonucleotide-induced therapeutic DNA damage-like responses in cancer cells

10 August 2017

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POT1 and TRF2 cooperate to maintain telomeric integrity

12 July 2018

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12 July 2018

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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

12 July 2018

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The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

12 July 2018

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12 July 2018

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TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

12 July 2018

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A DNA damage checkpoint response in telomere-initiated senescence

12 July 2018

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DNA damage induces transcriptional activation of p73 by removing C-EBP repression on E2F1

12 July 2018

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12 July 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

12 July 2018

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12 July 2018

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Evidence that exposure of the telomere 3' overhang sequence induces senescence

12 July 2018

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Different telomere damage signaling pathways in human and mouse cells

12 July 2018

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12 July 2018

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Induction of apoptosis by telomere 3' overhang-specific DNA.

12 July 2018

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12 July 2018

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12 July 2018

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Platinum compounds in the treatment of advanced breast cancer

12 July 2018

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Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

12 July 2018

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851376

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

12 July 2018

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Stimulation of melanogenesis by DNA oligonucleotides: effect of size, sequence and 5' phosphorylation

12 July 2018

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Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851376

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851376

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851376

Characterisation of membrane oligonucleotide-binding proteins and oligonucleotide uptake in keratinocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851376

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851376

Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region

12 July 2018

1 reference

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Thymidine dinucleotides induce S phase cell cycle arrest in addition to increased melanogenesis in human melanocytes

12 July 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851376

Enhanced phosphorylation of p53 by ATM in response to DNA damage

12 July 2018

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Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

12 July 2018

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DNA damage induces phosphorylation of the amino terminus of p53

12 July 2018

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Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response

12 July 2018

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Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.

12 July 2018

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Tumor necrosis factor-alpha-induced apoptosis in a human keratinocyte cell line (HaCaT) is counteracted by transforming growth factor-alpha

12 July 2018

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Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids

12 July 2018

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Positional cloning of the Werner's syndrome gene

12 July 2018

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12 July 2018

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Characteristics of oligonucleotide uptake in human keratinocyte cultures

12 July 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

12 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

12 July 2018

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12 July 2018

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Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

12 July 2018

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Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and specific platinum accumulation

12 July 2018

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Phase II study of cis-dichlorodiammineplatinum(II) in advanced breast cancer

12 July 2018

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T-oligos augment UV-induced protective responses in human skin.

12 July 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia

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Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells

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Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents

25 September 2018

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21 January 2018

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12 December 2020

Concurrent radiotherapy and taxane chemotherapy in patients with locoregional recurrence of breast cancer. A retrospective analysis

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12 December 2020

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

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12 December 2020

Histone H2A variant synthesis in aging human diploid cells

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12 December 2020

Targeting the kinesin Eg5 to monitor siRNA transfection in mammalian cells

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An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

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A rapid in vitro screening system for the identification and evaluation of anticancer drugs

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Identifiers

DOI

10.1186/BCR1646

1 reference

Dimensions Publication ID

10 August 2017

0 references

1 reference

10 August 2017

1 reference