Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress (Q35707277)

9 August 2017

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title

Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress (English)

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9 August 2017

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Andrey Y Abramov

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Michael R Duchen

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Laura Canevari

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9 August 2017

language of work or name

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1 March 2004

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9 August 2017

published in

Neurochemical Research

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

637-650

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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

9 August 2017

cites work

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12 December 2020

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

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Microglial signalling cascades in neurodegenerative disease.

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Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abeta-mediated neurotoxicity

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Intracellular APP processing and A beta production in Alzheimer disease

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12 December 2020

beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria

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12 December 2020

Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis

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12 December 2020

Intracellular calcium changes in neuronal cells induced by Alzheimer's beta-amyloid protein are blocked by estradiol and cholesterol

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Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease.

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Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

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12 December 2020

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

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12 December 2020

Effect of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures

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12 December 2020

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity

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12 December 2020

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE.

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12 December 2020

Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion

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12 December 2020

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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12 December 2020

Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures

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12 December 2020

Intraneuronal Abeta42 accumulation in human brain.

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12 December 2020

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

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12 December 2020

Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease

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12 December 2020

Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.

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12 December 2020

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

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12 December 2020

Brain Cytochrome Oxidase in Alzheimer's Disease

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12 December 2020

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

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12 December 2020

Expression of apoptosis related proteins in brains of patients with Alzheimer's disease

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12 December 2020

Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons

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12 December 2020

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

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12 December 2020

Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides.

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12 December 2020

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

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12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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12 December 2020

Effect of beta-amyloid peptide fragment 25-35 on nonselective permeability of mitochondria

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12 December 2020

Widespread peroxynitrite-mediated damage in Alzheimer's disease

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12 December 2020

Aging and Alzheimer's disease: lessons from the Nun Study.

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12 December 2020

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

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12 December 2020

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

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12 December 2020

Abeta(25-35) and Abeta(1-40) act on different calcium channels in CA1 hippocampal neurons

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12 December 2020

Attenuation of beta-amyloid neurotoxicity in vitro by potassium-induced depolarization

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12 December 2020

The metallobiology of Alzheimer's disease

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12 December 2020

Zn2+ interaction with Alzheimer amyloid beta protein calcium channels

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12 December 2020

Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells.

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12 December 2020

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

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12 December 2020

Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease

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12 December 2020

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

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12 December 2020

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

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12 December 2020

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

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12 December 2020

Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma

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12 December 2020

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

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12 December 2020

Brain Energy Metabolizing Enzymes in Alzheimer's Disease: α‐Ketoglutarate Dehydrogenase Complex and Cytochrome Oxidasea

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12 December 2020

Secretion of Alzheimer beta/A4 protein (1-40) and intracellular retention of beta/A4 protein (1-42) in transfected COS cells

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12 December 2020

Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation

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12 December 2020

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

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12 December 2020

Chronic exposure of NG108-15 cells to amyloid beta peptide (A beta(1-42)) abolishes calcium influx via N-type calcium channels

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12 December 2020

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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12 December 2020

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

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12 December 2020

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

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12 December 2020

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation

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12 December 2020

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

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12 December 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

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12 December 2020

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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12 December 2020

Amyloid beta protein-(1-42) forms calcium-permeable, Zn2+-sensitive channel

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12 December 2020

Amyloid beta protein enhances the clearance of extracellular L-glutamate by cultured rat cortical astrocytes

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12 December 2020

Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

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12 December 2020

Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells

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12 December 2020

Immunocytochemical demonstration of cytochrome c oxidase with an immunoperoxidase method: a specific stain for mitochondria in formalin-fixed and paraffin-embedded human tissues

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12 December 2020

Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways

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12 December 2020

Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion.

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12 December 2020

'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease

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12 December 2020

Glutathione pathways in the brain.

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12 December 2020

Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

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12 December 2020

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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12 December 2020

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

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12 December 2020

Are reactive oxygen species involved in Alzheimer's disease?

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12 December 2020

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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12 December 2020

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

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12 December 2020

The gene defects responsible for familial Alzheimer's disease

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12 December 2020

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

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12 December 2020

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

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12 December 2020

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

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12 December 2020

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

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12 December 2020

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

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12 December 2020

Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease.

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12 December 2020

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease.

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12 December 2020

Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.

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12 December 2020

Functional mitochondria are required for amyloid beta-mediated neurotoxicity

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12 December 2020

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

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12 December 2020

Extracellular amyloid formation and associated pathology in neural grafts

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12 December 2020

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

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12 December 2020

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

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12 December 2020

Aggregation of beta-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer's disease brain.

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12 December 2020

No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice

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12 December 2020

Amyloid-beta promotes calcium influx and neurodegeneration via stimulation of L voltage-sensitive calcium channels rather than NMDA channels in cultured neurons

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12 December 2020

Priming of monocyte respiratory burst by beta-amyloid fragment (25-35)

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane

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12 December 2020

Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease

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12 December 2020

Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle

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12 December 2020

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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12 December 2020

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

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12 December 2020

Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques

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12 December 2020

Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease

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12 December 2020

Amyloid beta peptide induces necrosis rather than apoptosis

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12 December 2020

Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines

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12 December 2020

DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology.

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12 December 2020

CD36 mediates the innate host response to beta-amyloid

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12 December 2020

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease

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12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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12 December 2020

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

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12 December 2020

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease.

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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12 December 2020

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity.

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12 December 2020

Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain

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12 December 2020

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

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12 December 2020

No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type

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12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

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12 December 2020

Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels.

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12 December 2020

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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12 December 2020

10.1023/B:NERE.0000014834.06405.AF

Identifiers

DOI

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Dimensions Publication ID

9 August 2017

1028966479

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