Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease (Q35698969)

9 August 2017

title

Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease (English)

1 reference

9 August 2017

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Puneet Garg

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Tae-Ju Park

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Tom Curran

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David J Salant

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Britta George

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9 August 2017

Rakesh Verma

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9 August 2017

Abdulsalam A Soofi

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9 August 2017

Jidong Zhang

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9 August 2017

Laura Giardino

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9 August 2017

Larisa Ryzhova

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9 August 2017

Duncan B Johnstone

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9 August 2017

Hetty Wong

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9 August 2017

Deepak Nihalani

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9 August 2017

Steven K Hanks

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9 August 2017

Maria Pia Rastaldi

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9 August 2017

Lawrence B Holzman

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9 August 2017

language of work or name

English

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publication date

17 January 2012

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Journal of Clinical Investigation

9 August 2017

published in

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9 August 2017

volume

122

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9 August 2017

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9 August 2017

page(s)

674-692

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Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane

9 August 2017

cites work

1 reference

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Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome

12 July 2018

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Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L

12 July 2018

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Inhibition of podocyte FAK protects against proteinuria and foot process effacement.

12 July 2018

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Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture

12 July 2018

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Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis

12 July 2018

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Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

12 July 2018

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Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement

12 July 2018

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Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.

12 July 2018

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Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

12 July 2018

1 reference

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A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors

12 July 2018

1 reference

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Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome

12 July 2018

1 reference

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Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Clinical impact of research on the podocyte slit diaphragm

12 July 2018

1 reference

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Cardiovascular and craniofacial defects in Crk-null mice

12 July 2018

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Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

The genetic basis of FSGS and steroid-resistant nephrosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Essential role of Gas6 for glomerular injury in nephrotoxic nephritis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Beyond the RING: CBL proteins as multivalent adapters

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

The integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk coupling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Aminopeptidase A: a nephritogenic target antigen of nephrotoxic serum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

FAK integrates growth-factor and integrin signals to promote cell migration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Nephrin localizes to the slit pore of the glomerular epithelial cell

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Nephrotoxic antiserum identifies a beta 1-integrin on rat glomerular epithelial cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Adhering Junction Dynamics in the Testis Are Regulated by an Interplay of β1-Integrin and Focal Adhesion Complex-Associated Proteins

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Two gene fragments that direct podocyte-specific expression in transgenic mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Podocyte-specific expression of cre recombinase in transgenic mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266791

Decay-accelerating factor confers protection against complement-mediated podocyte injury in acute nephrotoxic nephritis

15 November 2018

1 reference

12 December 2020

Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor

1 reference

12 December 2020

Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis

1 reference

12 December 2020

Glomerular Epithelium: Structural Alterations Induced by Polycations

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI60070

1 reference

9 August 2017

1 reference

9 August 2017

1 reference