Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virions (Q35689608)

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scientific article published on 16 November 2011

Language	Label	Description	Also known as
English	Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virions	scientific article published on 16 November 2011

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virions (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Simian immunodeficiency virus

0 references

1 reference

based on heuristic

inferred from title

monoclonal antibody

1 reference

based on heuristic

inferred from title

author name string

Ramesh Rathinakumar

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Moumita Dutta

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Ping Zhu

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Welkin E Johnson

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Kenneth H Roux

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

0 references

publication date

16 November 2011

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Journal of Virology

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Europe PubMed Central

PubMed publication ID

9 August 2017

86

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1820-1831

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.

1 reference

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HIV Type 1 Env Precursor Cleavage State Affects Recognition by Both Neutralizing and Nonneutralizing gp41 Antibodies

1 reference

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Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

1 reference

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Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution

1 reference

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Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding

1 reference

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In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1

1 reference

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Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

1 reference

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Role of HIV membrane in neutralization by two broadly neutralizing antibodies

1 reference

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Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L

1 reference

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Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

1 reference

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Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region

1 reference

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Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions

1 reference

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Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1

1 reference

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A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

1 reference

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Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

1 reference

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In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth

1 reference

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27 July 2018

Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1.

1 reference

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27 July 2018

Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

1 reference

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Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia

1 reference

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27 July 2018

Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

1 reference

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Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.

1 reference

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Molecular architecture of native HIV-1 gp120 trimers

1 reference

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Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41

1 reference

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27 July 2018

The broadly neutralizing anti-human immunodeficiency virus type 1 4E10 monoclonal antibody is better adapted to membrane-bound epitope recognition and blocking than 2F5.

1 reference

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27 July 2018

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

1 reference

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27 July 2018

Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion

1 reference

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The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design

1 reference

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A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

1 reference

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Reassessment of autoreactivity of the broadly neutralizing HIV antibodies 4E10 and 2F5 and retrospective analysis of clinical safety data

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In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.

1 reference

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Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection

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AIDS virus envelope spike structure

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The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes

1 reference

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

1 reference

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An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10

1 reference

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Monoclonal antibodies to phosphatidylinositol phosphate neutralize human immunodeficiency virus type 1: role of phosphate-binding subsites

1 reference

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Type-specific epitopes targeted by monoclonal antibodies with exceptionally potent neutralizing activities for selected strains of human immunodeficiency virus type 1 map to a common region of the V2 domain of gp120 and differ only at single positio

1 reference

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Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa

1 reference

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Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype B

1 reference

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Distribution and three-dimensional structure of AIDS virus envelope spikes

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Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma

1 reference

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27 July 2018

Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.

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Neutralization of HIV-1 primary isolate by ELDKWA-specific murine monoclonal antibodies

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Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

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27 July 2018

Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles

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Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10.

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Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

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Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

1 reference

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The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.

1 reference

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Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes.

1 reference

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Identification of a conserved domain of the HIV-1 transmembrane protein gp41 which interacts with cholesteryl groups

1 reference

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Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies

1 reference

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Antigenic properties of the human immunodeficiency virus transmembrane glycoprotein during cell-cell fusion

1 reference

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The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.

1 reference

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27 July 2018

Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus

1 reference

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Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins

1 reference

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27 July 2018

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264345

27 July 2018

Immunoreactivity of intact virions of human immunodeficiency virus type 1 (HIV-1) reveals the existence of fewer HIV-1 immunotypes than genotypes

1 reference

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27 July 2018

Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.

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27 July 2018

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

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27 July 2018

Dissociation of gp120 from HIV-1 virions induced by soluble CD4.

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25 September 2018

Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes.

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25 September 2018

Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes

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25 September 2018

Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors

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25 September 2018

Distinct mechanisms of lipid bilayer perturbation induced by peptides derived from the membrane-proximal external region of HIV-1 gp41.

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25 September 2018

Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10.

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25 September 2018

Interactions of HIV-1 antibodies 2F5 and 4E10 with a gp41 epitope prebound to host and viral membrane model systems

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25 September 2018

Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity

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25 September 2018

Membrane association and epitope recognition by HIV-1 neutralizing anti-gp41 2F5 and 4E10 antibodies.

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25 September 2018

Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization.

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25 September 2018

Specific phospholipid recognition by human immunodeficiency virus type-1 neutralizing anti-gp41 2F5 antibody

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25 September 2018

The membranes' role in the HIV-1 neutralizing monoclonal antibody 2F5 mode of action needs re-evaluation.

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25 September 2018

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

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25 September 2018

Trimeric membrane-anchored gp41 inhibits HIV membrane fusion.

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25 September 2018

Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions

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25 September 2018

HIV-1 gp41 envelope residues 650-685 exposed on native virus act as a lectin to bind epithelial cell galactosyl ceramide

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25 September 2018

Mechanisms of viral membrane fusion and its inhibition

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25 September 2018

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

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12 December 2020

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The effect of sCD4 on the binding and accessibility of HIV-1 gp41 MPER epitopes to human monoclonal antibodies

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12 December 2020

based on heuristic

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Synthesis and analysis of the membrane proximal external region epitopes of HIV-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22090143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4E10 and 2F5 monoclonal antibodies: binding specificities to phospholipids, tolerance, and clinical safety issues

1 reference

https://pubmed.ncbi.nlm.nih.gov/22090143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.05489-11

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

0 references

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