Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection. (Q35670114)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17360564%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection (English)

1 reference

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27 December 2019

1 reference

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27 December 2019

Annette Oxenius

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27 December 2019

Paola Agnellini

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27 December 2019

Petra Wolint

series ordinal

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27 December 2019

Julia Cahenzli

series ordinal

1 reference

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27 December 2019

Urs Karrer

series ordinal

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27 December 2019

language of work or name

English

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publication date

7 March 2007

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

27 December 2019

published in

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27 December 2019

volume

104

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27 December 2019

issue

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27 December 2019

page(s)

4565-4570

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Interleukin-10 determines viral clearance or persistence in vivo

27 December 2019

cites work

1 reference

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Resolution of a chronic viral infection after interleukin-10 receptor blockade

27 July 2018

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Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

27 July 2018

1 reference

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PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

27 July 2018

1 reference

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

27 July 2018

1 reference

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

27 July 2018

1 reference

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27 July 2018

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

27 July 2018

1 reference

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Restoring function in exhausted CD8 T cells during chronic viral infection

27 July 2018

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Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells

27 July 2018

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Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses

27 July 2018

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The Evolution of Antigen-Specific CD8+T Cell Responses after Natural Primary Infection of Humans with Epstein-Barr Virus

27 July 2018

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

27 July 2018

1 reference

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Lineage relationship and protective immunity of memory CD8 T cell subsets

27 July 2018

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T cell failure in hepatitis C virus infection

27 July 2018

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Lymphocytic choriomeningitis virus and immunology

27 July 2018

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Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells

27 July 2018

1 reference

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CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses

27 July 2018

1 reference

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

27 July 2018

1 reference

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Dissecting the host response to a gamma-herpesvirus

27 July 2018

1 reference

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Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungs

27 July 2018

1 reference

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Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells

27 July 2018

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Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.

27 July 2018

1 reference

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A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon

27 July 2018

1 reference

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27 July 2018

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Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.

27 July 2018

1 reference

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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

27 July 2018

1 reference

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Analysis of successful immune responses in persons infected with hepatitis C virus

27 July 2018

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27 July 2018

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Viral immune evasion due to persistence of activated T cells without effector function

27 July 2018

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

27 July 2018

1 reference

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

27 July 2018

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Hepatitis B virus immunopathogenesis

27 July 2018

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Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

27 July 2018

1 reference

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Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

27 July 2018

1 reference

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Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections

27 July 2018

1 reference

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Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Pathogenesis of murine cytomegalovirus infection

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Memory inflation: continuous accumulation of antiviral CD8+ T cells over time.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Molecular and functional profiling of memory CD8 T cell differentiation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Ablation of CD8 and CD4 T cell responses by high viral loads

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Skewed maturation of memory HIV-specific CD8 T lymphocytes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Phenotypic analysis of antigen-specific T lymphocytes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

CD8+ T-cell memory to viruses

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815473

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

25 September 2018

1 reference

12 December 2020

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

1 reference

12 December 2020

Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice

1 reference

12 December 2020

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

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Identifiers

DOI

10.1073/PNAS.0610335104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17360564%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17360564%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

17360564

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17360564%20AND%20SRC:MED&resulttype=core&format=json