An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. (Q35665032)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903676%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening (English)

1 reference

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12 February 2020

0 references

0 references

1 reference

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12 February 2020

Anh Tuan Nguyen

1 reference

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12 February 2020

Chor Hui Vivien Koh

1 reference

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12 February 2020

Jan M Spitsbergen

1 reference

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12 February 2020

Serguei Parinov

1 reference

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12 February 2020

Zhiyuan Gong

1 reference

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12 February 2020

publication date

8 September 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903676%20AND%20SRC:MED&resulttype=core&format=json

Disease Models & Mechanisms

12 February 2020

published in

1 reference

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12 February 2020

volume

1 reference

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12 February 2020

issue

1 reference

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12 February 2020

page(s)

63-72

1 reference

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A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

12 February 2020

cites work

1 reference

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Targeted therapies for hepatocellular carcinoma.

12 July 2018

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Iron Levels in Hepatocytes and Portal Tract Cells Predict Progression and Outcomes of Patients With Advanced Chronic Hepatitis C

12 July 2018

1 reference

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Zebrafish Models for Cancer

12 July 2018

1 reference

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Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo

12 July 2018

1 reference

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Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival

12 July 2018

1 reference

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

12 July 2018

1 reference

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

12 July 2018

1 reference

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Genetic models of cancer in zebrafish

12 July 2018

1 reference

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

12 July 2018

1 reference

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Molecular targeted therapies in hepatocellular carcinoma

12 July 2018

1 reference

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Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

12 July 2018

Targeting oncogenic Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Trans-kingdom transposition of the maize dissociation element

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Hepatocellular carcinoma pathogenesis: from genes to environment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

In vivo drug discovery in the zebrafish

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Hepatoblastoma in an adult A case report and clinical review of literatures

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Targeting RAS signalling pathways in cancer therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Cancer. Addiction to oncogenes--the Achilles heal of cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Increased MAPK Expression and Activity in Primary Human Hepatocellular Carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255544

Histopathological classification of hepatocellular carcinoma.

12 July 2018

1 reference

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Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish.

25 September 2018

1 reference

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Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation.

25 September 2018

1 reference

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

25 September 2018

1 reference

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Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.

25 September 2018

1 reference

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BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

25 September 2018

1 reference

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Myc-induced T cell leukemia in transgenic zebrafish

25 September 2018

1 reference

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Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21903676

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/DMM.008367

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903676%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903676%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

21903676

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903676%20AND%20SRC:MED&resulttype=core&format=json