Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro (Q35641801)

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scientific article published on 13 November 2006

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English	Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro	scientific article published on 13 November 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro (English)

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Europe PubMed Central

PubMed publication ID

9 August 2017

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Amato J. Giaccia

6

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Amato J Giaccia

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Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Yi Pan

1

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Europe PubMed Central

PubMed publication ID

9 August 2017

Kyle D Mansfield

2

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Europe PubMed Central

PubMed publication ID

9 August 2017

Cara C Bertozzi

3

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Europe PubMed Central

PubMed publication ID

9 August 2017

Viktoriya Rudenko

4

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Europe PubMed Central

PubMed publication ID

9 August 2017

Denise A Chan

5

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Europe PubMed Central

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9 August 2017

M Celeste Simon

7

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9 August 2017

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publication date

13 November 2006

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9 August 2017

Molecular and Cellular Biology

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9 August 2017

27

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Europe PubMed Central

PubMed publication ID

9 August 2017

3

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Europe PubMed Central

PubMed publication ID

9 August 2017

912-925

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Europe PubMed Central

PubMed publication ID

9 August 2017

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800695

27 July 2018

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

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Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

1 reference

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27 July 2018

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

1 reference

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

1 reference

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

1 reference

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

1 reference

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27 July 2018

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

1 reference

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Negative and positive regulation of HIF-1: a complex network

1 reference

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Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

1 reference

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A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha.

1 reference

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27 July 2018

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

1 reference

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27 July 2018

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors

1 reference

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Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

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Oxygen sensing by HIF hydroxylases

1 reference

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The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

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Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

1 reference

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27 July 2018

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

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27 July 2018

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

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A role for mitochondrial enzymes in inherited neoplasia and beyond

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

1 reference

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27 July 2018

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

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27 July 2018

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

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27 July 2018

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

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27 July 2018

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

1 reference

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27 July 2018

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

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27 July 2018

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

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Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

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Tumour suppression by the human von Hippel-Lindau gene product

1 reference

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

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Prolyl hydroxylase half reaction: peptidyl prolyl-independent decarboxylation of alpha-ketoglutarate

1 reference

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Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

1 reference

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

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Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha

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The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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Regulation of angiogenesis by hypoxia: role of the HIF system

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Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway

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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

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The function of ascorbate with respect to prolyl 4-hydroxylase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17101781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17101781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ROS: really involved in oxygen sensing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17101781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01223-06

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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