Nuclear transport and cancer: from mechanism to intervention (Q35633427)

9 August 2017

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title

Nuclear transport and cancer: from mechanism to intervention (English)

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9 August 2017

Pamela A Silver

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9 August 2017

Tweeny R Kau

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9 August 2017

Jeffrey C Way

series ordinal

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9 August 2017

language of work or name

English

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publication date

1 February 2004

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9 August 2017

published in

Nature Reviews Cancer

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

106-117

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Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy.

9 August 2017

cites work

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High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores

21 January 2018

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The nuclear pore complex: from molecular architecture to functional dynamics

21 January 2018

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Proteomic analysis of the mammalian nuclear pore complex

21 January 2018

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The nuclear pore complex as a transport machine.

21 January 2018

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The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm

21 January 2018

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Transport between the cell nucleus and the cytoplasm

21 January 2018

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Nucleocytoplasmic transport: the soluble phase

21 January 2018

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

21 January 2018

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The dynamics of karyopherin-mediated nuclear transport

21 January 2018

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Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene

21 January 2018

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Signal-mediated nuclear transport in proliferating and growth-arrested BALB/c 3T3 cells

21 January 2018

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Aberrant rel/nfkb genes and activity in human cancer

21 January 2018

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The Rel/NF-kappa B family: friend and foe.

21 January 2018

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NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

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Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit

21 January 2018

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I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

21 January 2018

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I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

21 January 2018

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Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

21 January 2018

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

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Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

21 January 2018

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Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

21 January 2018

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Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

21 January 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines

21 January 2018

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PTEN1 is frequently mutated in primary endometrial carcinomas

21 January 2018

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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

21 January 2018

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Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells

21 January 2018

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Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

21 January 2018

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The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

21 January 2018

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

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Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

21 January 2018

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Regulation and function of the p53 tumor suppressor protein

21 January 2018

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Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

21 January 2018

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Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein

21 January 2018

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

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A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

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The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

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C-terminal ubiquitination of p53 contributes to nuclear export

21 January 2018

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Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

21 January 2018

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Clinical implications of the p53 tumor-suppressor gene

21 January 2018

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

21 January 2018

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Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

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Subcellular localization of accumulated p53 in ovarian cancer cells

21 January 2018

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Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells

21 January 2018

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Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

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Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

21 January 2018

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Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

21 January 2018

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Parc: a cytoplasmic anchor for p53.

21 January 2018

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A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

21 January 2018

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Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

21 January 2018

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Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1.

21 January 2018

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A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle

21 January 2018

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Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB.

21 January 2018

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Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.

21 January 2018

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The ins and outs of APC and beta-catenin nuclear transport

21 January 2018

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Regulation of tumor suppressors by nuclear-cytoplasmic shuttling

21 January 2018

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

21 January 2018

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APC mutations occur early during colorectal tumorigenesis

21 January 2018

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Mutations of the APC (adenomatous polyposis coli) gene

21 January 2018

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Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription

21 January 2018

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beta-catenin can be transported into the nucleus in a Ran-unassisted manner

21 January 2018

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Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

21 January 2018

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Evolutionary specialization of the nuclear targeting apparatus

21 January 2018

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Translocation of β-catenin into the nucleus independent of interactions with FG-rich nucleoporins

21 January 2018

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Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

21 January 2018

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Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

21 January 2018

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APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export

21 January 2018

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The APC tumour suppressor has a nuclear export function.

21 January 2018

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Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor

21 January 2018

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Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53.

21 January 2018

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Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1

21 January 2018

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Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor

21 January 2018

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Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis

21 January 2018

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The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle

21 January 2018

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CSE1L/CAS: its role in proliferation and apoptosis

21 January 2018

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The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

21 January 2018

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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

21 January 2018

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Hox genes in vertebrate development

21 January 2018

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CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

21 January 2018

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The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

21 January 2018

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Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

21 January 2018

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CRM1 is an export receptor for leucine-rich nuclear export signals

21 January 2018

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CRM1 is responsible for intracellular transport mediated by the nuclear export signal

21 January 2018

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Evidence for a role of CRM1 in signal-mediated nuclear protein export

21 January 2018

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Exportin 1 (Crm1p) is an essential nuclear export factor

21 January 2018

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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

21 January 2018

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A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135)

21 January 2018

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The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae

21 January 2018

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Phase I trial of elactocin

21 January 2018

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 January 2018

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Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis

21 January 2018

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Architecture and design of the nuclear pore complex

21 January 2018

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Breast cancer banishes p27 from nucleus

31 March 2020

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Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations

31 March 2020

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Chromatin remodeling factor encoded by ini1 induces G1 arrest and apoptosis in ini1-deficient cells

31 March 2020

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The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines

31 March 2020

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Antisense Inhibition of CAS, the Human Homologue of the Yeast Chromosome Segregation Gene CSE1, Interferes with Mitosis in HeLa Cells

31 March 2020

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The hCSE1/CAS Protein Is Phosphorylated by HeLa Extracts and MEK-1: MEK-1 Phosphorylation May Modulate the Intracellular Localization of CAS

31 March 2020

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Chromosome banding studies in 106 cases of chronic myelogenous leukemia

31 March 2020

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NUP98 gene fusions in hematologic malignancies.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1274

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9 August 2017

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