SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation (Q35621518)

9 August 2017

title

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation (English)

1 reference

9 August 2017

Mingjia Tan

1 reference

9 August 2017

Yongchao Zhao

1 reference

9 August 2017

Sun-Jung Kim

1 reference

9 August 2017

Margaret Liu

1 reference

9 August 2017

Lijun Jia

1 reference

9 August 2017

Thomas L Saunders

1 reference

9 August 2017

Yuan Zhu

1 reference

9 August 2017

Yi Sun

1 reference

9 August 2017

language of work or name

English

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publication date

23 November 2011

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9 August 2017

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inferred from page(s)

published in

Developmental Cell

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

1062-1076

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RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins

9 August 2017

cites work

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27 July 2018

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27 July 2018

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Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

27 July 2018

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27 July 2018

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Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation

27 July 2018

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The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation

27 July 2018

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27 July 2018

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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

27 July 2018

1 reference

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

27 July 2018

1 reference

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

27 July 2018

1 reference

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

27 July 2018

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SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

27 July 2018

1 reference

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27 July 2018

1 reference

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Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

27 July 2018

1 reference

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Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

27 July 2018

1 reference

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25 September 2018

1 reference

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25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping

25 September 2018

1 reference

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Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder.

25 September 2018

1 reference

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Analysis of RING finger genes required for embryogenesis in C. elegans.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241850

Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22118770

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of the sensitive to apoptosis gene, SAG, as a prognostic marker in nonsmall cell lung cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22118770

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.DEVCEL.2011.09.014

1 reference

9 August 2017

1 reference

9 August 2017

1 reference