Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization (Q35591798)

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scientific article published on October 1988

Language	Label	Description	Also known as
English	Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization	scientific article published on October 1988

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

3

object named as

C R Kahn

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

S S Reddy

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

V Lauris

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

0 references

publication date

1 October 1988

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

82

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1359-1365

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Stimulation of glucose incorporation and amino acid transport by insulin and an insulin-like growth factor in fibroblasts with defective insulin receptors cultured from a patient with leprechaunism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

A case of leprechaunism with severe hyperinsulinemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Fibroblasts from a Patient with Leprechaunism Are Resistant to Insulin, Epidermal Growth Factor, and Somatomedin C*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Receptors for insulinlike growth factor I are defective in fibroblasts cultured from a patient with leprechaunism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Mechanisms of insulin resistance in cultured fibroblasts from a patient with leprechaunism: impaired post-binding actions of insulin and multiplication-stimulating activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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27 July 2018

Leprechaunism: an inherited defect in a high-affinity insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Structural analysis of normal and mutant insulin receptors in fibroblasts cultured from families with leprechaunism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin

1 reference

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27 July 2018

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1 reference

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27 July 2018

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Genetics of the insulin receptor defect in a patient with extreme insulin resistance.

1 reference

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27 July 2018

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

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27 July 2018

Insulin-stimulated receptor phosphorylation appears normal in cultured Epstein-Barr virus-transformed lymphocyte cell lines derived from patients with extreme insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

1 reference

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27 July 2018

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Primary defect of insulin receptors in skin fibroblasts cultured from an infant with leprechaunism and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Insulin resistance due to a defect distal to the insulin receptor: Demonstration in a patient with leprechaunism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

27 July 2018

Cell culture studies on patients with extreme insulin resistance. II. Abnormal biological responses in cultured fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

26 September 2018

Phosphorylation activates the insulin receptor tyrosine protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

26 September 2018

Defect in Phosphorylation of Insulin Receptors in Cells from an Insulin-Resistant Patient with Normal Insulin Binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

26 September 2018

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442692

26 September 2018

Polypeptide hormone receptor phosphorylation: is there a role in receptor-mediated endocytosis of human growth hormone?

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of synthetic insulin receptor peptides by the insulin receptor kinase and evidence that the preferred sequence containing Tyr-1150 is phosphorylated in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in insulin binding and autophosphorylation of erythrocyte insulin receptors in patients with syndromes of severe insulin resistance and their parents

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor kinase following internalization in isolated rat adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leprechaunism: a euphemism for a rare familial disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin binding and insulin-dependent phosphorylation of the insulin receptor solubilized from human erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 Assays of protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/3049675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI113739

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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