Approaches for the sequence-specific knockdown of mRNA. (Q35597089)

9 August 2017

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title

Approaches for the sequence-specific knockdown of mRNA. (English)

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9 August 2017

Lisa J Scherer

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9 August 2017

John J Rossi

series ordinal

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9 August 2017

publication date

1 December 2003

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9 August 2017

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

1457-1465

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

9 August 2017

cites work

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7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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7 January 2021

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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7 January 2021

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

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7 January 2021

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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7 January 2021

A hitchhiker's guide to antisense and nonantisense biochemical pathways

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7 January 2021

Innovations in the use of antisense oligonucleotides

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7 January 2021

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

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7 January 2021

Comparison of binding of mixed ribose-deoxyribose analogues of CUCU to a ribozyme and to GGAGAA by equilibrium dialysis: evidence for ribozyme specific interactions with 2' OH groups

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7 January 2021

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

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7 January 2021

Frequent use of the same tertiary motif by self-folding RNAs

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7 January 2021

Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid

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7 January 2021

A nucleotide sequence rearrangement distinguishes two isolates of satellite tobacco ringspot virus RNA.

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7 January 2021

Nucleotide sequence and newly formed phosphodiester bond of spontaneously ligated satellite tobacco ringspot virus RNA.

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7 January 2021

Random mutations to evaluate the role of bases at two important single-stranded regions of genomic HDV ribozyme

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7 January 2021

A site-specific self-cleavage reaction performed by a novel RNA in Neurospora mitochondria

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7 January 2021

In vitro selection of functional nucleic acids

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7 January 2021

Enzymatic activity of the conserved core of a group I self-splicing intron

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7 January 2021

Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing

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7 January 2021

Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA.

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7 January 2021

Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors

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7 January 2021

Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts

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7 January 2021

Ribozyme-mediated trans-splicing of a trinucleotide repeat.

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7 January 2021

Ribonuclease P: a ribonucleoprotein enzyme

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7 January 2021

External Guide Sequences for an RNA Enzyme

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7 January 2021

Trans-activation of the Tetrahymena ribozyme by its P2-2.1 domains

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7 January 2021

Secondary structure content of the HDV ribozyme in 95% formamide

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7 January 2021

A ribozyme derived from the catalytic subunit of RNase P from Escherichia coli is highly effective in inhibiting replication of herpes simplex virus 1.

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7 January 2021

RNase P ribozymes selected in vitro to cleave a viral mRNA effectively inhibit its expression in cell culture

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7 January 2021

RNase P-mediated inhibition of cytomegalovirus protease expression and viral DNA encapsidation by oligonucleotide external guide sequences

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7 January 2021

Engineered RNase P ribozymes inhibit gene expression and growth of cytomegalovirus by increasing rate of cleavage and substrate binding.

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7 January 2021

Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli

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7 January 2021

Structural and ionic requirements for self-cleavage of virusoid RNAs and trans self-cleavage of viroid RNA

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7 January 2021

'Hairpin' catalytic RNA model: evidence for helices and sequence requirement for substrate RNA.

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7 January 2021

Simple RNA enzymes with new and highly specific endoribonuclease activities

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7 January 2021

Ribozymes as potential anti-HIV-1 therapeutic agents.

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7 January 2021

Nucleic-acid therapeutics: basic principles and recent applications

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7 January 2021

Emerging clinical applications of RNA

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7 January 2021

Anti-gene therapy: the use of ribozymes to inhibit gene function

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7 January 2021

A general purpose RNA-cleaving DNA enzyme

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7 January 2021

Mechanism and utility of an RNA-cleaving DNA enzyme

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7 January 2021

Deoxyribozymes: new activities and new applications

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7 January 2021

Catalytic DNA: a novel tool for gene suppression

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7 January 2021

Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes).

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7 January 2021

Role for a bidentate ribonuclease in the initiation step of RNA interference

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7 January 2021

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

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7 January 2021

Small RNAs correspond to centromere heterochromatic repeats

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7 January 2021

Establishment and maintenance of a heterochromatin domain

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7 January 2021

Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing

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7 January 2021

Activation of the interferon system by short-interfering RNAs

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7 January 2021

The nuclear RNase III Drosha initiates microRNA processing

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7 January 2021

Asymmetry in the assembly of the RNAi enzyme complex

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7 January 2021

Sequence requirements for micro RNA processing and function in human cells

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7 January 2021

Role of microRNAs in plant and animal development

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7 January 2021

Vertebrate microRNA genes

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7 January 2021

RNAi: nature abhors a double-strand

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7 January 2021

siRNAs can function as miRNAs

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7 January 2021

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

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7 January 2021

Expanding small RNA interference

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7 January 2021

RNA interference in human cells is restricted to the cytoplasm

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7 January 2021

Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA.

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7 January 2021

Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.

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7 January 2021

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

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7 January 2021

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

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7 January 2021

The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript

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7 January 2021

Ribozymes, genomics and therapeutics

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7 January 2021

Functional siRNAs and miRNAs Exhibit Strand Bias

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7 January 2021

Functional colocalization of ribozymes and target mRNAs in Drosophila oocytes

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7 January 2021

mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymes

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7 January 2021

Intracellular expression and function of antisense catalytic RNAs

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7 January 2021

Colocalizing ribozymes with substrate RNAs to increase their efficacy as gene inhibitors

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7 January 2021

Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells

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7 January 2021

Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures

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7 January 2021

A mutation-independent therapeutic strategem for osteogenesis imperfecta

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7 January 2021

Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.

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7 January 2021

Expression profiling reveals off-target gene regulation by RNAi

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7 January 2021

Genomewide view of gene silencing by small interfering RNAs

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7 January 2021

CpG motifs in bacterial DNA and their immune effects

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7 January 2021

Induction of acute phase response genes in keratinocytes following exposure to oligodeoxynucleotides

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7 January 2021

Induction of an interferon response by RNAi vectors in mammalian cells

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7 January 2021

Establishment of conditional vectors for hairpin siRNA knockdowns

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7 January 2021

siRNA function in RNAi: a chemical modification analysis

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7 January 2021

Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA.

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7 January 2021

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7 January 2021

Three-dimensional structure of a hammerhead ribozyme

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7 January 2021

Numbering system for the hammerhead

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7 January 2021

Identifiers

DOI

10.1038/NBT915

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Dimensions Publication ID

9 August 2017

1003713111

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