Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis (Q35589168)

9 August 2017

title

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis (English)

1 reference

9 August 2017

1 reference

María A Blasco

0 references

Raquel Blanco

1 reference

9 August 2017

Purificación Muñoz

series ordinal

1 reference

9 August 2017

Juana M Flores

series ordinal

1 reference

9 August 2017

Peter Klatt

series ordinal

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9 August 2017

publication date

1 January 2007

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9 August 2017

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

206-220

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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

9 August 2017

cites work

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TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

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Increased p53 activity does not accelerate telomere-driven ageing

27 July 2018

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Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

27 July 2018

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The first molecular details of ALT in human tumor cells

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27 July 2018

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27 July 2018

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

27 July 2018

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Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis

27 July 2018

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Homologous recombination generates T-loop-sized deletions at human telomeres

27 July 2018

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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

27 July 2018

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Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells

27 July 2018

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Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition

27 July 2018

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Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

27 July 2018

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DNA damage foci at dysfunctional telomeres

27 July 2018

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Evolving views of telomerase and cancer

27 July 2018

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Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development

27 July 2018

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New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

27 July 2018

1 reference

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Protection of mammalian telomeres

27 July 2018

1 reference

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

27 July 2018

1 reference

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27 July 2018

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27 July 2018

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

27 July 2018

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Control of human telomere length by TRF1 and TRF2

27 July 2018

1 reference

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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

27 July 2018

1 reference

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

27 July 2018

1 reference

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

27 July 2018

1 reference

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27 July 2018

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27 July 2018

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TRF2 Protects Human Telomeres from End-to-End Fusions

27 July 2018

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

27 July 2018

1 reference

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Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

27 July 2018

1 reference

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Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure

27 July 2018

1 reference

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Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

27 July 2018

1 reference

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XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

27 July 2018

1 reference

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Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

26 September 2018

1 reference

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Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

26 September 2018

1 reference

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ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

26 September 2018

1 reference

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A DNA damage checkpoint response in telomere-initiated senescence

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Many ways to telomere dysfunction: in vivo studies using mouse models

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Essential role of mouse telomerase in highly proliferative organs

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

Identification of human Rap1: implications for telomere evolution

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

DNA methyltransferases control telomere length and telomere recombination in mammalian cells

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770903

[1] Isolation and utilization of epidermal keratinocytes for oncogene research

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17234886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of the TRF2 telomeric protein in cancer and ageing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17234886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.406207

1 reference

9 August 2017

1 reference

9 August 2017

1 reference