Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling (Q35570447)

8 August 2017

title

Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling (English)

1 reference

8 August 2017

author

Monika Schäfer-Korting

object named as

Monika Schäfer-Korting

1 reference

8 August 2017

Pilar Rivera Gil

0 references

Heinfried H Radeke

0 references

Burkhard Kleuser

1 reference

8 August 2017

Christina D Keller

1 reference

8 August 2017

Markus Tölle

1 reference

8 August 2017

Markus van der Giet

1 reference

8 August 2017

Jerold Chun

1 reference

8 August 2017

language of work or name

English

0 references

publication date

1 January 2007

1 reference

The American Journal of Pathology

8 August 2017

published in

1 reference

8 August 2017

volume

170

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8 August 2017

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8 August 2017

page(s)

281-292

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Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1.

8 August 2017

cites work

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The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells

27 July 2018

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Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase

27 July 2018

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Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52.

27 July 2018

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FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

27 July 2018

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27 July 2018

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27 July 2018

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Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation

27 July 2018

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HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.

27 July 2018

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27 July 2018

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S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).

27 July 2018

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27 July 2018

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The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

27 July 2018

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Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

27 July 2018

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Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta

27 July 2018

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Sphingosine-1-phosphate: an enigmatic signalling lipid

27 July 2018

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Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing

27 July 2018

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The immune modulator FTY720 targets sphingosine 1-phosphate receptors

27 July 2018

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

27 July 2018

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Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3

27 July 2018

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

27 July 2018

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TGF-beta signal transduction

27 July 2018

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FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homin

27 July 2018

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Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

27 July 2018

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Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

26 September 2018

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Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells

26 September 2018

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Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer

26 September 2018

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FTY720 prevents renal T-cell infiltration after ischemia/reperfusion injury

26 September 2018

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Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate

26 September 2018

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Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.

26 September 2018

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Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis

26 September 2018

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Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1762708

Immunosuppressant FTY720 inhibits thymocyte emigration

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17200201

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17200201

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2353/AJPATH.2007.060485

1 reference

8 August 2017

1 reference

8 August 2017

1 reference