Resistance to antifolates (Q35567272)

8 August 2017

1 reference

title

Resistance to antifolates (English)

1 reference

8 August 2017

main subject

cell surface receptor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576850

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

24 March 2024

Rongbao Zhao

1 reference

8 August 2017

I. David Goldman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576850

24 March 2024

language of work or name

English

0 references

publication date

1 October 2003

1 reference

8 August 2017

20 October 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14576850

full work available at URL

24 March 2024

https://www.nature.com/articles/1206946.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

https://www.nature.com/articles/1206946

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

24 March 2024

1 reference

8 August 2017

1 reference

8 August 2017

1 reference

8 August 2017

page(s)

7431-7457

1 reference

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

8 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Loss of Folic Acid Exporter Function with Markedly Augmented Folate Accumulation in Lipophilic Antifolate-resistant Mammalian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Transfection with a cDNA encoding a Ser31 or Ser34 mutant human dihydrofolate reductase into Chinese hamster ovary and mouse marrow progenitor cells confers methotrexate resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Protection of bone marrow cells from toxicity of chemotherapeutic agents targeted toward thymidylate synthase by transfer of mutant forms of human thymidylate synthase cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Effect of methotrexate on intracellular folate pools in purified myeloid precursor cells from normal human bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Polygammaglutamyl metabolites of methotrexate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Folate status and the safety profile of antifolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Retroviral Transduction of a Mutant Dihydrofolate Reductase-Thymidylate Synthase Fusion Gene into Murine Marrow Cells Confers Resistance to Both Methotrexate and 5-Fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Polyglutamation of methotrexate. Is methotrexate a prodrug?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A Bicistronic Retroviral Vector for Protecting Hematopoietic Cells Against Antifolates and P-Glycoprotein Effluxed Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Glutamyl hydrolase. pharmacological role and enzymatic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Structural requirements for anion substrates of the methotrexate transport system in L1210 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Is the multidrug transporter a flippase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Na+ and pH dependence of 5-methyltetrahydrofolic acid and methotrexate transport in freshly isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Transport of methotrexate into PC-3 human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Gene amplification in a leukemic patient treated with methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Biochemical pharmacology of the lipophilic antifolate, trimetrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Studies with a mathematical model of folate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Reactivation of dihydrofolate reductase inhibited by methotrexate or aminopterin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Increased methotrexate toxicity due to concurrent probenecid administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Reversal of Methotrexate Cytotoxicity to Human Bone Marrow Cells and Leukemic K562 Cells by Leucovorin: Methotrexate Polyglutamates Formation as a Possible Important Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

MRP3, an organic anion transporter able to transport anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Folate-mediated targeting: from diagnostics to drug and gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Mechanisms of resistance to N-[5-[N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Folate-mediated delivery of macromolecular anticancer therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Molecular and cellular biology of the human reduced folate carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Membrane transport of folates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Phenotypic Expression in Escherichia coli and Nucleotide Sequence of Two Chinese Hamster Lung Cell cDNAs Encoding Different Dihydrofolate Reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Strategy for the treatment of acute myelogenous leukemia based on folate receptor beta-targeted liposomal doxorubicin combined with receptor induction using all-trans retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Molecular cloning of the human placental folate transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Genomic organization of the human folate receptor genes on chromosome 11q13

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Functional effects of amino acid substitutions at residue 33 of human thymidylate synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Weekly lometrexol with daily oral folic acid is appropriate for phase II evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of t

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Molecular aspects of renal anionic drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Tight Binding of Folate Substrates and Inhibitors to Recombinant Mouse Glycinamide Ribonucleotide Formyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-gamma-glutamate synthetase by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Expression of a novel double-mutant dihydrofolate reductase-cytidine deaminase fusion gene confers resistance to both methotrexate and cytosine arabinoside

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

ATP-dependent efflux of 2,4-dinitrophenyl-S-glutathione. Properties of two distinct transport systems in inside-out vesicles from L1210 cells and a variant subline with altered efflux of methotrexate and cholate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Methotrexate polyglutamate synthesis by cultured human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Interaction of folylpolyglutamates with enzymes in one-carbon metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Translational regulation as a novel mechanism for the development of cellular drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Gastrointestinal absorption of folates and antifolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Carrier-mediated membrane transport of folates in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

In vivo selection of hematopoietic stem cells transduced with DHFR-expressing retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation of a family of organic anion transporters from human liver and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Comparison of methotrexate resistance conferred by a mutated dihydrofolate reductase (DHFR) cDNA in two different retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

The folate receptor in central nervous system malignancies of childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Clustering of GPI-Anchored Folate Receptor Independent of Both Cross-Linking and Association with Caveolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Divergent regulation of dihydrofolate reductase between malaria parasite and human host

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Cyclic core dendrimer as a new kind of vector for gene transfer into mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

RFC-1 gene expression regulates folate absorption in mouse small intestine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

The role of thymidylate synthase in cellular regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Effects of metabolic deprivation on methotrexate transport in L1210 leukemia cells: further evidence for separate influx and efflux systems with different energetic requirements

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Role of the membrane-associated folate binding protein (folate receptor) in methotrexate transport by human KB cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Dihydrofolate Reductase Protein Inhibits Its Own Translation by Binding to Dihydrofolate Reductase mRNA Sequences within the Coding Region

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Translational regulation of the synthesis of dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Growth inhibition by homofolate in tumor cells utilizing a high-affinity folate binding protein as a means for folate internalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Anion exchange mechanism for transport of methotrexate in L1210 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Regulatory aspects of the glutamylation of methotrexate in cultured hepatoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Impact of Overexpression of the Reduced Folate Carrier (RFC1), an Anion Exchanger, on Concentrative Transport in Murine L1210 Leukemia Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206946

7 January 2021

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

A simple method for the specific detection of Ren-1 renin

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Compartmentation of folate-mediated one-carbon metabolism in eukaryotes

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Inhibitory effects of prostaglandin A1 on membrane transport of folates mediated by both the reduced folate carrier and ATP-driven exporters

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells.

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Evidence for the existence of a carrier-mediated folate uptake mechanism in human colonic luminal membranes

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Differences in Folylpolyglutamate Synthetase and Dihydrofolate Reductase Expression in Human B-Lineage versus T-Lineage Leukemic Lymphoblasts: Mechanisms for Lineage Differences in Methotrexate Polyglutamylation and Cytotoxicity

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

The characteristics of the membrane transport of amethopterin and the naturally occurring folates

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

On the nature of permeability of sarcoma-180 cells to amethopterin in vitro

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Intracellular phosphate and its possible role as an exchange anion for active transport of methotrexate in L1210 cells

24 March 2024

106

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Regulation of folate-binding protein gene expression by DNA methylation in methotrexate-resistant KB cells

24 March 2024

120

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

24 March 2024

122

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Inhibition of human dihydrofolate reductase by antifolyl polyglutamates

24 March 2024

151

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Reduced folate derivatives are endogenous substrates for cMOAT in rats

24 March 2024

152

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Ankylosing spondylitis: current approaches to treatment

24 March 2024

183

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Potocytosis. Robert Feulgen Lecture

24 March 2024

188

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Growth of ovarian-carcinoma cell lines at physiological folate concentration: effect on folate-binding protein expression in vitro and in vivo

24 March 2024

190

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

24 March 2024

197

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities

24 March 2024

209

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 Cells

24 March 2024

237

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier

24 March 2024

250

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

24 March 2024

258

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

24 March 2024

270

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake

24 March 2024

286

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

24 March 2024

291

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies

24 March 2024

295

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity

24 March 2024

317

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues

24 March 2024

322

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier

24 March 2024

326

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206946

24 March 2024

Identifiers

1 reference

Dimensions Publication ID

8 August 2017

1015819318

0 references

1 reference