Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity (Q35544553)

8 August 2017

title

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity (English)

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8 August 2017

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8 August 2017

Martina Muckenthaler

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8 August 2017

Jian Wang

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8 August 2017

Guohua Chen

series ordinal

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8 August 2017

Bruno Galy

series ordinal

1 reference

8 August 2017

Kostas Pantopoulos

series ordinal

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8 August 2017

language of work or name

English

0 references

publication date

1 February 2004

1 reference

Molecular and Cellular Biology

8 August 2017

published in

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

954-965

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Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

8 August 2017

cites work

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12 July 2018

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Multiple, conserved iron-responsive elements in the 3'-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2.

12 July 2018

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Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant

12 July 2018

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Activation of iron regulatory protein-1 by oxidative stress

12 July 2018

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12 July 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

12 July 2018

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12 July 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

12 July 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

12 July 2018

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Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

12 July 2018

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

12 July 2018

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Iron regulatory proteins and the molecular control of mammalian iron metabolism

12 July 2018

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Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

12 July 2018

1 reference

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Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2.

12 July 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

12 July 2018

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Hypoxia post-translationally activates iron-regulatory protein 2.

12 July 2018

1 reference

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Involvement of heme in the degradation of iron-regulatory protein 2.

12 July 2018

1 reference

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Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins

12 July 2018

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

12 July 2018

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Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships

12 July 2018

1 reference

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Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Rapid responses to oxidative stress mediated by iron regulatory protein.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome

12 July 2018

1 reference

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Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron. IRP-2 inactivation requires translation of another protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Oxygen and iron regulation of iron regulatory protein 2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=321427

Ascorbic acid enhances iron-induced ferritin translation in human leukemia and hepatoma cells

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14729944

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ascorbic Acid Enhances Ferritin mRNA Translation by an IRP/Aconitase Switch

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14729944

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.24.3.954-965.2004

1 reference

8 August 2017

1 reference

8 August 2017

1 reference