Hydroxyurea induces de novo copy number variants in human cells (Q35409753)

8 August 2017

title

Hydroxyurea induces de novo copy number variants in human cells (English)

1 reference

8 August 2017

1 reference

Martin F Arlt

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8 August 2017

Alev Cagla Ozdemir

1 reference

8 August 2017

Shanda R Birkeland

1 reference

8 August 2017

Thomas E Wilson

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8 August 2017

Thomas W Glover

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8 August 2017

language of work or name

English

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publication date

10 October 2011

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Proceedings of the National Academy of Sciences of the United States of America

8 August 2017

published in

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8 August 2017

volume

108

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8 August 2017

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8 August 2017

page(s)

17360-17365

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The effect of the intra-S-phase checkpoint on origins of replication in human cells

8 August 2017

cites work

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12 July 2018

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Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

12 July 2018

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Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing

12 July 2018

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Diversity of human copy number variation and multicopy genes

12 July 2018

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12 July 2018

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Hydroxyurea (therapeutics and mechanism): Metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications

12 July 2018

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The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up

12 July 2018

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Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies

12 July 2018

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12 July 2018

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12 July 2018

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Global screening and extended nomenclature for 230 aphidicolin-inducible fragile sites, including 61 yet unreported ones

12 July 2018

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Signatures of mutation and selection in the cancer genome

12 July 2018

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12 July 2018

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Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma.

12 July 2018

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Advances in the use of hydroxyurea

12 July 2018

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Origins and functional impact of copy number variation in the human genome

12 July 2018

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The role of DNA copy number variation in schizophrenia.

12 July 2018

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Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.

12 July 2018

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Copy number variation in human health, disease, and evolution

12 July 2018

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Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation

12 July 2018

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Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture

12 July 2018

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Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes

12 July 2018

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LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization

12 July 2018

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Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

12 July 2018

1 reference

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Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants

12 July 2018

1 reference

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Support for the involvement of large copy number variants in the pathogenesis of schizophrenia

12 July 2018

1 reference

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A microhomology-mediated break-induced replication model for the origin of human copy number variation

12 July 2018

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Copy-number variations associated with neuropsychiatric conditions

12 July 2018

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Replication fork movement sets chromatin loop size and origin choice in mammalian cells

12 July 2018

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Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

12 July 2018

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Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles

12 July 2018

1 reference

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Replication stress induces tumor-like microdeletions in FHIT/FRA3B

12 July 2018

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A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders

12 July 2018

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

12 July 2018

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Paired-end mapping reveals extensive structural variation in the human genome

12 July 2018

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Use of array CGH in the evaluation of dysmorphology, malformations, developmental delay, and idiopathic mental retardation

12 July 2018

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Copy number variation in the genome; the human DMD gene as an example

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Global variation in copy number in the human genome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Segmental duplications and copy-number variation in the human genome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Detection of large-scale variation in the human genome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Large-scale copy number polymorphism in the human genome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Genomic rearrangements resulting in PLP1 deletion occur by nonhomologous end joining and cause different dysmyelinating phenotypes in males and females

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

The human genome browser at UCSC

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Mechanism of action of hydroxyurea

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Hydroxyurea in sickle cell disease: What will it take to change practice?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Hydroxurea and sickle cell disease: Its been a long, long time coming

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Growing dictyate oocytes, but not early preimplantation embryos, of the mouse display high levels of DNA homologous recombination by single-strand annealing and lack DNA nonhomologous end joining

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198378

Duplications in the DMD gene

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21987784

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Somatic mosaicism for copy number variation in differentiated human tissues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21987784

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1109272108

1 reference

8 August 2017

0 references

1 reference

8 August 2017

1 reference