PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation (Q35311785)

7 August 2017

title

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation (English)

1 reference

7 August 2017

0 references

Gordon J Freeman

1 reference

7 August 2017

Nikolaos Patsoukis

1 reference

7 August 2017

Kankana Bardhan

1 reference

7 August 2017

Pranam Chatterjee

1 reference

7 August 2017

Duygu Sari

1 reference

7 August 2017

Bianling Liu

1 reference

7 August 2017

Lauren N Bell

1 reference

7 August 2017

Edward D Karoly

1 reference

7 August 2017

Victoria Petkova

1 reference

7 August 2017

Pankaj Seth

1 reference

7 August 2017

Lequn Li

1 reference

7 August 2017

Vassiliki A Boussiotis

1 reference

7 August 2017

language of work or name

English

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publication date

26 March 2015

1 reference

7 August 2017

published in

Nature Communications

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7 August 2017

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7 August 2017

page(s)

6692

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Creative Commons Attribution 4.0 International

7 August 2017

start time

26 March 2015

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

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Desnutrin/ATGL activates PPARδ to promote mitochondrial function for insulin secretion in islet β cells

27 July 2018

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PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2

27 July 2018

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Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells

27 July 2018

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Metabolic switching and fuel choice during T-cell differentiation and memory development

27 July 2018

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Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

27 July 2018

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FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling

27 July 2018

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

27 July 2018

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n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

27 July 2018

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Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

27 July 2018

1 reference

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Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

27 July 2018

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Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling

27 July 2018

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The PD-1 pathway in tolerance and autoimmunity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation

27 July 2018

1 reference

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Spare respiratory capacity, oxidative stress and excitotoxicity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems

27 July 2018

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mTOR regulates memory CD8 T-cell differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.

27 July 2018

1 reference

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PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

27 July 2018

1 reference

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Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Fat metabolism links germline stem cells and longevity in C. elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

27 July 2018

1 reference

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Restoring function in exhausted CD8 T cells during chronic viral infection

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Regulation of T lymphocyte metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

On respiratory impairment in cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

The CD28 signaling pathway regulates glucose metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

CTLA-4: new insights into its biological function and use in tumor immunotherapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Glutamine metabolism in lymphocytes of the rat.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Posttranscriptional control of T cell effector function by aerobic glycolysis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Amino acids and immune function

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth

26 September 2018

1 reference

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SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4389235

Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and disease

26 September 2018

1 reference

12 December 2020

Dietary fish oil decreases secretion of T helper (Th) 1-type cytokines by a direct effect on murine splenic T cells but enhances secretion of a Th2-type cytokine by an effect on accessory cells

1 reference

12 December 2020

CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells

1 reference

12 December 2020

Comparison between transport and degradation of leucine and glutamine by peripheral human lymphocytes exposed to concanavalin A

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS7692

1 reference

7 August 2017

0 references

1 reference

7 August 2017

1 reference