A novel small-molecule MRCK inhibitor blocks cancer cell invasion (Q35307266)

7 August 2017

title

A novel small-molecule MRCK inhibitor blocks cancer cell invasion (English)

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7 August 2017

Michael F Olson

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Mathieu Unbekandt

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7 August 2017

Daniel R Croft

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7 August 2017

Diane Crighton

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7 August 2017

Mokdad Mezna

1 reference

7 August 2017

Duncan McArthur

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7 August 2017

Patricia McConnell

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7 August 2017

Alexander W Schüttelkopf

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7 August 2017

Simone Belshaw

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7 August 2017

Andrew Pannifer

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7 August 2017

Mairi Sime

1 reference

7 August 2017

Justin Bower

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7 August 2017

Martin Drysdale

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7 August 2017

publication date

5 October 2014

1 reference

Cell Communication and Signaling

7 August 2017

published in

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7 August 2017

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7 August 2017

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Creative Commons Attribution 4.0 International

7 August 2017

start time

5 October 2014

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April 2022 Public Data File from Crossref

copyrighted

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cites work

PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.

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Ser1333 phosphorylation indicates ROCKI activation

27 July 2018

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Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

27 July 2018

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Kinome Render: a stand-alone and web-accessible tool to annotate the human protein kinome tree

27 July 2018

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Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

27 July 2018

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ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.

27 July 2018

1 reference

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Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase

27 July 2018

1 reference

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Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration

27 July 2018

1 reference

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Features and development of Coot

27 July 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

27 July 2018

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27 July 2018

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Molecular replacement with MOLREP

27 July 2018

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The nuts and bolts of AGC protein kinases

27 July 2018

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MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices

27 July 2018

1 reference

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Non-muscle myosin II takes centre stage in cell adhesion and migration

27 July 2018

1 reference

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A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow

27 July 2018

1 reference

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The actin cytoskeleton in cancer cell motility

27 July 2018

1 reference

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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

27 July 2018

1 reference

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Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Refinement of macromolecular structures by the maximum-likelihood method

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

The protein kinase complement of the human genome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

The role of ligand efficiency metrics in drug discovery.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

The benzophenanthridine alkaloid chelerythrine binds to DNA by intercalation: photophysical aspects and thermodynamic results of iminium versus alkanolamine interaction

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

ROCKII Ser1366 phosphorylation reflects the activation status.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Hallmarks of Cancer: The Next Generation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Gene expression profiling predicts clinical outcome of breast cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

Chelerythrine is a potent and specific inhibitor of protein kinase C.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4195943

10.1186/PREACCEPT-1467335606136283

26 September 2018

Identifiers

DOI

reason for deprecated rank

redirect

1 reference

10.1186/S12964-014-0054-X

7 August 2017

1 reference

SciGraph

https://scigraph.springernature.com/pub.10.1186/s12964-014-0054-x

Dimensions Publication ID

9 September 2019

1 reference

https://scigraph.springernature.com/pub.10.1186/s12964-014-0054-x

9 September 2019

1 reference

7 August 2017

1 reference