Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma (Q35238424)

7 August 2017

title

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma (English)

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7 August 2017

Ann M Lozier

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7 August 2017

Maria E Rich

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7 August 2017

Anissa Pedersen Grawe

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7 August 2017

Anderson S Peck

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7 August 2017

Ping Zhao

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7 August 2017

Anthony Ting-Tung Chang

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7 August 2017

Jeffrey P Bond

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7 August 2017

Giselle Saulnier Sholler

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7 August 2017

language of work or name

English

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publication date

1 January 2015

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7 August 2017

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

196-206

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Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells

7 August 2017

cites work

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Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene.

27 July 2018

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LIN28/LIN28B: an emerging oncogenic driver in cancer stem cells

27 July 2018

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Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma

27 July 2018

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The Lin28/let-7 axis regulates glucose metabolism

27 July 2018

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Targeting metabolic remodeling in glioblastoma multiforme

27 July 2018

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Stem Cells in Normal Development and Cancer

27 July 2018

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The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation

27 July 2018

1 reference

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Lin28 promotes transformation and is associated with advanced human malignancies

27 July 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

27 July 2018

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Defining the role of mTOR in cancer

27 July 2018

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Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification

27 July 2018

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The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

27 July 2018

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Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation

27 July 2018

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Glucose metabolism and cancer

27 July 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

27 July 2018

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RAS is regulated by the let-7 microRNA family

27 July 2018

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On the Origin of Cancer Cells

27 July 2018

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Development of difluoromethylornithine (DFMO) as a chemoprevention agent.

27 July 2018

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Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Ornithine decarboxylase activity in the rat and human colon

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver

27 July 2018

1 reference

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AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

26 September 2018

1 reference

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Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Hypoxia, HIF1 and glucose metabolism in the solid tumour

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Tumor cell metabolism imaging

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas

26 September 2018

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Extending positron emission tomography scan utility to high-risk neuroblastoma: fluorine-18 fluorodeoxyglucose positron emission tomography as sole imaging modality in follow-up of patients

26 September 2018

1 reference

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Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381588

Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps

26 September 2018

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Tumor Suppression with a Combination of α-Difluoromethyl Ornithine and Interferon

26 September 2018

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12 December 2020

Potentiation of antitumor and antimetastatic activities of alpha-difluoromethylornithine by interferon inducers

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12 December 2020

Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo

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12 December 2020

Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas

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12 December 2020

Effect of polyamine depletion in vivo by DL-alpha-difluoromethylornithine on functionally distinct populations of tumoricidal effector cells in normal and tumor-bearing mice

1 reference

12 December 2020

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12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.2768

0 references

PMC publication ID

4381588

1 reference

7 August 2017

1 reference