Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. (Q35237466)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

review article

5 references

26 August 2020

24 December 2020

8 February 2021

17 February 2023

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

3 April 2019

cell surface receptor

1 reference

31 July 2019

1 reference

15 December 2019

1 reference

22 December 2019

1 reference

26 August 2020

1 reference

24 December 2020

tumor suppressor gene

1 reference

24 December 2020

1 reference

8 February 2021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Iannis Aifantis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Philmo Oh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

language of work or name

English

0 references

publication date

1 September 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

13 February 2020

26 September 2011

4 references

26 August 2020

24 December 2020

8 February 2021

17 February 2023

9 references

3 April 2019

31 July 2019

15 December 2019

22 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

26 August 2020

24 December 2020

8 February 2021

17 February 2023

208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

page(s)

1931-1935

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

13 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

The mutational landscape of head and neck squamous cell carcinoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch pathway activation induces neuroblastoma tumor cell growth arrest

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch signalling in solid tumours: a little bit of everything but not all the time

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Alterations of the Notch pathway in lung cancer.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Recent insights into the role of Notch signaling in tumorigenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch1 functions as a tumor suppressor in mouse skin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

Notch signaling in bulge stem cells is not required for selection of hair follicle fate.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182047

26 September 2018

Identifiers

DOI

10.1084/JEM.20111855

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21948802

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948802%20AND%20SRC:MED&resulttype=core&format=json