An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. (Q35212577)

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12 February 2020

title

An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma (English)

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12 February 2020

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Nidal Boulos

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Clinton F Stewart

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Amar Gajjar

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Jennifer M Atkinson

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Karen Wright

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Robert A Johnson

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Helen Poppleton

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Kumarasamypet M Mohankumar

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Clementine Féau

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Timothy Phoenix

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Paul Gibson

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Liqin Zhu

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Yiai Tong

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Chris Eden

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David W Ellison

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Waldemar Priebe

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Dimpy Koul

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W K Alfred Yung

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Richard J Gilbertson

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publication date

1 September 2011

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volume

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issue

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12 February 2020

page(s)

384-399

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The cerebrospinal fluid provides a proliferative niche for neural progenitor cells

12 February 2020

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Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

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Exciting New Targets in Lung Cancer Therapy: ALK, IGF-1R, HDAC, and Hh

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Cross-species genomics matches driver mutations and cell compartments to model ependymoma

13 July 2018

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Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice

13 July 2018

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Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

13 July 2018

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Phase I trial of two schedules of vincristine, oral irinotecan, and temozolomide (VOIT) for children with relapsed or refractory solid tumors: a Children's Oncology Group phase I consortium study

13 July 2018

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The relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models.

13 July 2018

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13 July 2018

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Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

13 July 2018

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13 July 2018

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

13 July 2018

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The glial nature of embryonic and adult neural stem cells

13 July 2018

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13 July 2018

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Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study

13 July 2018

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Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.

13 July 2018

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13 July 2018

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Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

13 July 2018

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Chemotherapy for intracranial ependymomas

13 July 2018

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Topotecan for the treatment of recurrent or progressive central nervous system tumors - a pediatric oncology group phase II study

13 July 2018

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Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma

13 July 2018

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

13 July 2018

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SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression

13 July 2018

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Incidence patterns for ependymoma: a surveillance, epidemiology, and end results study.

26 September 2018

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EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts

26 September 2018

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Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

26 September 2018

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Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor

26 September 2018

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Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos

26 September 2018

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26 September 2018

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A phase I study of irinotecan administered on a weekly schedule in pediatric patients

26 September 2018

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

26 September 2018

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Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor

26 September 2018

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Validated liquid chromatographic determination of 5-fluorouracil in human plasma

26 September 2018

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Efficacy of systemic administration of irinotecan against neuroblastoma xenografts.

26 September 2018

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Acute lymphoblastic leukemia

26 September 2018

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12 December 2020

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Carboplatin pharmacokinetics in young children with brain tumors

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Continuous infusion of 5-fluorouracil plus low-dose cisplatin in tumor-bearing mice

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10.1016/J.CCR.2011.08.013

Identifiers

DOI

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12 February 2020

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12 February 2020

PubMed publication ID

21907928

1 reference

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