Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity (Q35210669)

7 August 2017

title

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity (English)

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7 August 2017

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1 reference

Jonathan Chow

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Michael R Krout

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Sangwon V Kim

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Maria Ciofani

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Fabio R Santori

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Nicolas Manel

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Dan R Littman

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7 August 2017

Jun R Huh

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7 August 2017

Monica W L Leung

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7 August 2017

Pengxiang Huang

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7 August 2017

Daniel A Ryan

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7 August 2017

Raghu R V Malapaka

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7 August 2017

Adolfo Cuesta

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7 August 2017

Juan J Lafaille

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7 August 2017

H Eric Xu

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7 August 2017

David Y Gin

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7 August 2017

Fraydoon Rastinejad

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7 August 2017

language of work or name

English

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publication date

27 March 2011

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7 August 2017

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7 August 2017

volume

472

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7 August 2017

issue

7344

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7 August 2017

page(s)

486-490

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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

7 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Novel therapeutic applications of cardiac glycosides

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Endogenous digitalis: pathophysiologic roles and therapeutic applications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

The digitalis-like steroid hormones: new mechanisms of action and biological significance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

A functional genomics strategy reveals Rora as a component of the mammalian circadian clock

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Reduction of digoxin to 20R-dihydrodigoxin by cultures of Eubacterium lentum

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Induction of intestinal Th17 cells by segmented filamentous bacteria

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Cardiotonic steroids on the road to anti-cancer therapy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Interactions between cardiac glycosides and sodium/potassium-ATPase: three-dimensional structure-activity relationship models for ligand binding to the E2-Pi form of the enzyme versus activity inhibition.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172133

Inactivation of Digoxin by the Gut Flora: Reversal by Antibiotic Therapy

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21441909

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE09978

1 reference

Dimensions Publication ID

7 August 2017

0 references

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7 August 2017

1 reference