Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR (Q35215434)

7 August 2017

title

Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR (English)

1 reference

7 August 2017

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21301226

23 November 2024

Yumay Chen

1 reference

7 August 2017

Chi-Fen Chen

series ordinal

1 reference

7 August 2017

Phang-Lang Chen

series ordinal

1 reference

7 August 2017

Daniel J. Riley

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21301226

23 November 2024

language of work or name

1 reference

15 February 2011

1 reference

full work available at URL

7 August 2017

1 reference

inferred from page(s)

https://www.tandfonline.com/doi/pdf/10.4161/cc.10.4.14814?needAccess=true

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21301226

https://europepmc.org/articles/PMC3173995

23 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21301226

https://europepmc.org/articles/PMC3173995?pdf=render

23 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21301226

https://doi.org/10.4161/cc.10.4.14814

23 November 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21301226

http://www.tandfonline.com/doi/pdf/10.4161/cc.10.4.14814

23 November 2024

1 reference

DOI

10.4161/CC.10.4.14814

https://api.crossref.org/works/10.4161/CC.10.4.14814

23 November 2024

1 reference

7 August 2017

1 reference

7 August 2017

1 reference

7 August 2017

page(s)

655-663

1 reference

Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability

7 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Pseudo-DNA damage response in senescent cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Profiling of UV-induced ATM/ATR signaling pathways.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

ATM and ATR: components of an integrated circuit

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

DNA-damage response pathways triggered by viral replication.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

NFBD1/Mdc1 mediates ATR-dependent DNA damage response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

ATR and ATRIP: partners in checkpoint signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

The many substrates and functions of ATM

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Histone variants of H2A and H3 families are regulated during in vitro aging in the same manner as during differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

Atm-deficient mice: a paradigm of ataxia telangiectasia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173995

The ATM-mediated DNA-damage response: taking shape.

28 July 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

21 January 2018

How cells activate ATR.

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.4.14814

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21301226

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21301226

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/CC.10.4.14814

1 reference

7 August 2017

1 reference

7 August 2017

1 reference