Hepatic glucose metabolism in humans--its role in health and disease (Q35214635)

7 August 2017

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title

Hepatic glucose metabolism in humans--its role in health and disease (English)

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7 August 2017

Michael Roden

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7 August 2017

Elisabeth Bernroider

series ordinal

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7 August 2017

publication date

1 September 2003

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Best Practice and Research: Clinical Endocrinology and Metabolism

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

365-383

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Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting

7 August 2017

cites work

1 reference

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7 January 2021

Nuclear magnetic resonance studies of hepatic glucose metabolism in humans.

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7 January 2021

Quantitation of basal endogenous glucose production in Type II diabetes: importance of the volume of distribution

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7 January 2021

Methods for measuring glycogen cycling

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7 January 2021

Metabolic control of hepatic gluconeogenesis during exercise

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7 January 2021

Role of fructose 2,6-bisphosphate in the control by glucagon of gluconeogenesis from various precursors in isolated rat hepatocytes

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7 January 2021

Regulation of glucose production by the liver

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7 January 2021

Specific features of glycogen metabolism in the liver

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7 January 2021

The role of glucose 6‐phosphate in the control of glycogen synthase

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7 January 2021

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

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7 January 2021

Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.

1 reference

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7 January 2021

Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects

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7 January 2021

Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity.

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7 January 2021

Mechanism of free fatty acid-induced insulin resistance in humans

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7 January 2021

Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man

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7 January 2021

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects

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7 January 2021

The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans

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7 January 2021

Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans

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7 January 2021

Direct and indirect effects of amino acids on hepatic glucose metabolism in humans

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7 January 2021

Glucagon and regulation of glucose metabolism

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

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7 January 2021

Effect of dietary protein intake on insulin secretion and glucose metabolism in insulin-dependent diabetes mellitus

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7 January 2021

Influence of Maturity-onset Diabetes on Splanchnic Glucose Balance After Oral Glucose Ingestion

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7 January 2021

Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans

1 reference

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7 January 2021

Severe Hyperglycemia: Effects of Rehydration on Endocrine Derangements and Blood Glucose Concentration

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs

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7 January 2021

On insulin action in vivo: the single gateway hypothesis

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7 January 2021

Lipid-dependent control of hepatic glycogen stores in healthy humans.

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Effect of fatty acids on glucose production and utilization in man

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Insulin-counteracting hormones: Their impact on glucose metabolism

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Novel peptides under development for the treatment of type 1 and type 2 diabetes mellitus

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7 January 2021

Carbohydrate storage in man: speculations and some quantitative considerations

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Renal glucose production during insulin-induced hypoglycemia in humans

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers

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7 January 2021

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

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7 January 2021

Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Liver and muscle glycogen in man after glucose and fructose infusion

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Glycogen: its mode of formation and contribution to hepatic glucose output in postabsorptive humans

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study

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7 January 2021

Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man

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7 January 2021

Quantifying the contribution of gluconeogenesis to glucose production in fasted human subjects using stable isotopes

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Mechanism by which metformin reduces glucose production in type 2 diabetes

1 reference

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7 January 2021

Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Substrates and the regulation of hepatic glycogen metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Regulation of endogenous glucose production after a mixed meal in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Initial splanchnic extraction of ingested glucose in normal man.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Effects of short-term improvement of insulin treatment and glycemia on hepatic glycogen metabolism in type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Reduction of hepatic glycogen synthesis and breakdown in patients with agenesis of the dorsal pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Pathways of glycogen repletion

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

The direct and indirect effects of insulin on hepatic glucose production in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Natural course of insulin resistance in type I diabetes

1 reference

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7 January 2021

Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus

1 reference

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7 January 2021

Hepatic glycogen studies in Indian diabetics

1 reference

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7 January 2021

Liver glycogen accumulation in unstable diabetes.

1 reference

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7 January 2021

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Chronic intraperitoneal insulin delivery, as compared with subcutaneous delivery, improves hepatic glucose metabolism in streptozotocin diabetic rats

1 reference

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7 January 2021

Insulin replacement therapy in diabetic rats using an osmotic pump normalizes expression of enzymes key to hepatic carbohydrate metabolism

1 reference

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7 January 2021

Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Continuous Subcutaneous Insulin Infusion Therapy Decreases Insulin Resistance in Type 1 Diabetes*

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Development of the human pancreas: variations and pathology. A tentative classification

1 reference

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7 January 2021

Agenesis of the dorsal pancreas in a woman with diabetes mellitus and in both of her sons

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Complete and partial agenesis of the dorsal pancreas within one family

1 reference

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7 January 2021

Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Nocturnal spikes of growth hormone secretion cause the dawn phenomenon in type 1 (insulin-dependent) diabetes mellitus by decreasing hepatic (and extrahepatic) sensitivity to insulin in the absence of insulin waning.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Insulin resistance, but normal basal rates of glucose production in patients with newly diagnosed mild diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Overnight normalization of glucose concentrations improves hepatic but not extrahepatic insulin action in subjects with type 2 diabetes mellitus

1 reference

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7 January 2021

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

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7 January 2021

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Short-Term Leptin-Dependent Inhibition of Hepatic Gluconeogenesis Is Mediated by Insulin Receptor Substrate-2

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Effects of short-term leptin exposure on triglyceride deposition in rat liver

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Splanchnic and leg exchange of free fatty acids in patients with liver cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Absolute quantification of the hepatic glycogen content in a patient with glycogen storage disease by 13C magnetic resonance spectroscopy

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https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Analysis of glycogen storage disease by in vivo 13C NMR: comparison of normal volunteers with a patient

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

In vivo 13C-NMR evaluation of glycogen content in a patient with glycogen storage disease

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Prolonged Suppression of Insulin Release by Insulin-Induced Hypoglycemia: Demonstration by C-Peptide Assay

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1521-690X%2803%2900031-9

7 January 2021

10.1016/S1521-690X(03)00031-9

Identifiers

DOI

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7 August 2017

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