High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control (Q35192655)

7 August 2017

title

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control (English)

1 reference

7 August 2017

0 references

Beatriz Mothe

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Christoph T Berger

0 references

Christian Brander

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Alessandro Sette

1 reference

7 August 2017

David A Price

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Bruce D Walker

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7 August 2017

Florencia Pereyra

1 reference

7 August 2017

John Sidney

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7 August 2017

Daniel C Douek

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7 August 2017

Jason M Brenchley

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7 August 2017

Nicole Frahm

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7 August 2017

Musie Ghebremichael

1 reference

7 August 2017

Kari L Hartman

1 reference

7 August 2017

Leah M Henry

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7 August 2017

Laura E Ruff

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7 August 2017

Vanessa Venturi

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7 August 2017

Daniel E Kaufmann

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7 August 2017

language of work or name

English

0 references

publication date

13 July 2011

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7 August 2017

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

9334-9345

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Escape from highly effective public CD8+ T-cell clonotypes by HIV

7 August 2017

cites work

1 reference

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Variable HIV peptide stability in human cytosol is critical to epitope presentation and immune escape

13 July 2018

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

13 July 2018

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Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire

13 July 2018

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Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

13 July 2018

1 reference

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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

13 July 2018

1 reference

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Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

13 July 2018

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HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity

13 July 2018

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Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences

13 July 2018

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Virological, immune and host genetics markers in the control of HIV infection

13 July 2018

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13 July 2018

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Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response

13 July 2018

1 reference

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Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

13 July 2018

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Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

13 July 2018

1 reference

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Programmed death-1 as a factor in immune exhaustion and activation in HIV infection

13 July 2018

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Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection

13 July 2018

1 reference

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HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

13 July 2018

1 reference

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Comparisons of CD8+ T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness

13 July 2018

1 reference

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

13 July 2018

1 reference

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Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells

13 July 2018

1 reference

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The molecular basis for public T-cell responses?

13 July 2018

1 reference

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Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus Clearance

13 July 2018

1 reference

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A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells

13 July 2018

1 reference

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Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype

13 July 2018

1 reference

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Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

13 July 2018

1 reference

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Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

13 July 2018

1 reference

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HLA alleles associated with slow progression to AIDS truly prefer to present HIV-1 p24.

13 July 2018

1 reference

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Extensive HLA class I allele promiscuity among viral CTL epitopes

13 July 2018

1 reference

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A novel functional CTL avidity/activity compartmentalization to the site of mucosal immunization contributes to protection of macaques against simian/human immunodeficiency viral depletion of mucosal CD4+ T cells

13 July 2018

1 reference

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The T cell repertoire in infection and vaccination: implications for control of persistent viruses

13 July 2018

1 reference

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Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells

13 July 2018

1 reference

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Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression

13 July 2018

1 reference

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Structural determinants of T-cell receptor bias in immunity

13 July 2018

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TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope

13 July 2018

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HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.

13 July 2018

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The challenges of host and viral diversity in HIV vaccine design

13 July 2018

1 reference

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Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa

13 July 2018

1 reference

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Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

13 July 2018

1 reference

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Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection

13 July 2018

1 reference

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HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load

13 July 2018

1 reference

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Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

13 July 2018

1 reference

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Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 infection from southern Africa

13 July 2018

1 reference

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Molecular mechanisms and biological significance of CTL avidity

13 July 2018

1 reference

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Preferential HLA usage in the influenza virus-specific CTL response.

13 July 2018

1 reference

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Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities

13 July 2018

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Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

13 July 2018

1 reference

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IMGT, the international ImMunoGeneTics database.

13 July 2018

1 reference

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T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

13 July 2018

1 reference

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Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy

13 July 2018

1 reference

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High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL.

13 July 2018

1 reference

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The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

13 July 2018

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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

13 July 2018

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Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy.

13 July 2018

1 reference

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Novel, cross-restricted, conserved, and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type 1 infection

13 July 2018

1 reference

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Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

13 July 2018

1 reference

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Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

13 July 2018

1 reference

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Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors

13 July 2018

1 reference

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Increased sensitivity to antigen in high avidity CD8+ T cells results from augmented membrane proximal T‐cell receptor signal transduction

13 July 2018

1 reference

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Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.

27 September 2018

1 reference

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Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques.

27 September 2018

1 reference

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Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.

27 September 2018

1 reference

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Large HIV-specific CD8 cytotoxic T-lymphocyte (CTL) clones reduce their overall size but maintain high frequencies of memory CTL following highly active antiretroviral therapy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

27 September 2018

1 reference

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The structure of H-2K(b) and K(bm8) complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance

27 September 2018

1 reference

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The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration

27 September 2018

1 reference

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Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype

27 September 2018

1 reference

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Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles

27 September 2018

1 reference

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Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

27 September 2018

1 reference

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Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection

27 September 2018

1 reference

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A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.

27 September 2018

1 reference

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Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load

27 September 2018

1 reference

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Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific.

27 September 2018

1 reference

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Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection

27 September 2018

1 reference

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CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

Evolution and transmission of stable CTL escape mutations in HIV infection

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165743

Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo

15 November 2018

1 reference

12 December 2020

HLA and AIDS: a cautionary tale

1 reference

12 December 2020

HLA-B molecules target more conserved regions of the HIV-1 proteome

1 reference

12 December 2020

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

1 reference

12 December 2020

Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development

1 reference

12 December 2020

Single T cell receptor-mediated recognition of an identical HIV-derived peptide presented by multiple HLA class I molecules

1 reference

12 December 2020

Identifiers

DOI

10.1128/JVI.00460-11

1 reference

7 August 2017

1 reference

7 August 2017

1 reference