Synaptotagmin I, a Ca2+ sensor for neurotransmitter release (Q35192506)

7 August 2017

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title

Synaptotagmin I, a Ca2+ sensor for neurotransmitter release (English)

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7 August 2017

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Tong Wey Koh

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7 August 2017

Hugo J Bellen

series ordinal

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7 August 2017

publication date

1 August 2003

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7 August 2017

published in

Trends in Neurosciences

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

413-422

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Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Short-term synaptic plasticity

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7 January 2021

Co-operative action a calcium ions in transmitter release at the neuromuscular junction

1 reference

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7 January 2021

Calcium dependence of presynaptic calcium current and post-synaptic response at the squid giant synapse

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7 January 2021

Properties of the larval neuromuscular junction in Drosophila melanogaster

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7 January 2021

Two components of transmitter release at a central synapse

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7 January 2021

Presynaptic calcium is increased during normal synaptic transmission and paired-pulse facilitation, but not in long-term potentiation in area CA1 of hippocampus

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7 January 2021

Probing fundamental aspects of synaptic transmission with strontium

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7 January 2021

Calcium sensitivity of glutamate release in a calyx-type terminal

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7 January 2021

Intracellular calcium dependence of transmitter release rates at a fast central synapse

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7 January 2021

Presynaptic strontium dynamics and synaptic transmission

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Genetic and molecular analysis of the synaptotagmin family

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmin: a calcium sensor on the synaptic vesicle surface

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. Definition of candidate Ca2+ sensors for the fast and slow components of neurotransmitter release

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Role of synaptotagmin in Ca2+-triggered exocytosis

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Mechanism of calcium-independent synaptotagmin binding to target SNAREs

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptic transmission persists in synaptotagmin mutants of Drosophila

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah

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7 January 2021

Drosophila genetics and the functions of synaptic proteins.

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7 January 2021

The effect on synaptic physiology of synaptotagmin mutations in Drosophila

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7 January 2021

Calcium-dependent transmitter secretion from fibroblasts: modulation by synaptotagmin I

1 reference

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7 January 2021

Transgenically encoded protein photoinactivation (FlAsH-FALI): acute inactivation of synaptotagmin I.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Clathrin-mediated endocytosis: membrane factors pull the trigger

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter release

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Fluorophore-assisted light inactivation: a high-throughput tool for direct target validation of proteins

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmins: C2-domain proteins that regulate membrane traffic

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmin I functions as a calcium regulator of release probability

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

SNARE complex formation is triggered by Ca2+ and drives membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

SNARE proteins contribute to calcium cooperativity of synaptic transmission

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Visualization of synaptotagmin I oligomers assembled onto lipid monolayers.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Integrin-mediated regulation of synaptic morphology, transmission, and plasticity.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Altered Synaptic Plasticity in Drosophila Memory Mutants with a Defective Cyclic AMP Cascade

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Inhibitory transmission mediated by asynchronous transmitter release

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900195-4

7 January 2021

10.1016/S0166-2236(03)00195-4

Identifiers

DOI

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7 August 2017

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