Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.

Evolutionary families of peptidases

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Families and clans of serine peptidases

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A new family of serine-type peptidases related to prolyl oligopeptidase

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Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). Enzyme nomenclature. Recommendations 1992. Supplement 3: corrections and additions (1995).

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CD26 antigen is a surface dipeptidyl peptidase IV (DPPIV) as characterized by monoclonal antibodies clone TII-19-4-7 and 4EL1C7.

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Identification of the bile canalicular cell surface molecule GP110 as the ectopeptidase dipeptidyl peptidase IV: an analysis by tissue distribution, purification and N-terminal amino acid sequence

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Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface

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Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene

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Structure of the mouse dipeptidyl peptidase IV (CD26) gene

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Comodulation of CXCR4 and CD26 in human lymphocytes

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Prolyl Oligopeptidase

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CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes.

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Development of a tertiary-structure model of the C-terminal domain of DPP IV.

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Threading with chemostructural restrictions method for predicting fold and functionally significant residues: application to dipeptidylpeptidase IV (DPP-IV).

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Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance.

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Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers

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Fibroblast activation protein: purification, epitope mapping and induction by growth factors

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Molecular cloning of seprase: a serine integral membrane protease from human melanoma

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Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts

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A role for dipeptidyl peptidase IV in suppressing the malignant phenotype of melanocytic cells

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Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex

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The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23

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Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease

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The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family.

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Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis

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Structures of prolyl oligopeptidase substrate/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue

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On the size of the active site in proteases. I. Papain

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Metabolism of glucagon by dipeptidyl peptidase IV (CD26).

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Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family

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Extended investigation of the substrate specificity of dipeptidyl peptidase IV from pig kidney

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Kinetic investigation of the hydrolysis of aminoacyl p-nitroanilides by dipeptidyl peptidase IV from human and pig kidney.

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Proline-dependent structural and biological properties of peptides and proteins

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Substrates containing phosphorylated residues adjacent to proline decrease the cleavage by proline-specific peptidases.

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Influence on proline-specific enzymes of a substrate containing the thioxoaminoacyl-prolyl peptide bond.

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Peptidase activity of glycylprolyl β-naphthylamidase from human submaxillary gland

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Isolation and characterization of dipeptidyl peptidase IV from human placenta

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Soluble dipeptidyl peptidase IV from terminal differentiated rat epidermal cells: purification and its activity on synthetic and natural peptides

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Distribution of a dipeptide naphthylamidase in rat tissues and its localisation by using diazo coupling and labeled antibody techniques

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Dipeptidyl peptidase IV, a kidney brush-border serine peptidase

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Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens

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Peptidyl ammonium methyl ketones as substrate analog inhibitors of proline-specific peptidases.

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Solution structures of active and inactive forms of the DP IV (CD26) inhibitor Pro-boroPro determined by NMR spectroscopy

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Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides

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Recent developments in inhibiting cysteine and serine proteases.

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In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-diphenyl-phosphonate (Prodipine).

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Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity

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Presence of adenosine deaminase on the surface of mononuclear blood cells: immunochemical localization using light and electron microscopy

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Direct association of adenosine deaminase with a T cell activation antigen, CD26

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Specific binding of adenosine deaminase but not HIV-1 transactivator protein Tat to human CD26.

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The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency

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Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV.

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The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression

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Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix.

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The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site

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Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family

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Comparative studies of the sugar chains of aminopeptidase N and dipeptidylpeptidase IV purified from rat kidney brush-border membrane

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Domain‐Specific N‐Glycosylation of the Membrane Glycoprotein Dipeptidylpeptidase IV (CD26) Influences its Subcellular Trafficking, Biological Stability, Enzyme Activity and Protein Folding

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NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.

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Temporal association of the N- and O-linked glycosylation events and their implication in the polarized sorting of intestinal brush border sucrase-isomaltase, aminopeptidase N, and dipeptidyl peptidase IV.

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Apical secretion and sialylation of soluble dipeptidyl peptidase IV are two related events

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In vivo modulation of the acidic N-glycans from rat liver dipeptidyl peptidase IV by N-propanoyl-D-mannosamine

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The significance of hypersialylation of dipeptidyl peptidase IV (CD26) in the inhibition of its activity by Tat and other cationic peptides. CD26: a subverted adhesion molecule for HIV peptide binding

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Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity.

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Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation

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Immunohistochemical localization of dipeptidyl aminopeptidase IV in rat kidney, liver, and salivary glands

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The cytoplasmic/transmembrane domain of dipeptidyl peptidase IV, a type II glycoprotein, contains an apical targeting signal that does not specifically interact with lipid rafts

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Studies on dipeptidyl(amino)peptidase IV (glycyl-proline naphthylamidase)

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Peptidases II. Localization of dipeptidylpeptidase IV (DPP IV). Histochemical and biochemical study

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Ultrastructural localization of dipeptidylpeptidase IV in the glomerulum of the rat kidney

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Intestinal epithelial cells secrete exosome-like vesicles

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Identification of dipeptidyl peptidase IV as a protein shared by the plasma membrane of hepatocytes and liver biomatrix

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Changes of X-prolyl dipeptidyl-aminopeptidase activity in developing rat brain

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Immunolocalization of dipeptidyl aminopeptidase (DAP IV) in the developing human brain

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Comparison of X-prolyl dipeptidyl-aminopeptidase activity in human cerebrospinal fluid with that in serum

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Histochemical evidence for the presence of dipeptidylpeptidase IV in the Schwann cells of skin unmyelinated axons

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Distribution of adenosine deaminase complexing protein (ADCP) in human tissues

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Dipeptidyl peptidase IV as a differentiation marker of the human endometrial glandular cells

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glycylprolyl β-naphthylamidase activity in human serum

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Functional role of CD26 on human B lymphocytes

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CD26 is expressed on a restricted subpopulation of dendritic cells in vivo

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Characterization of the 4C8 antigen involved in transendothelial migration of CD26(hi) T cells after tight adhesion to human umbilical vein endothelial cell monolayers

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CD26, let it cut or cut it down.

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Transcript imaging of the development of human T helper cells using oligonucleotide arrays

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Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter

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Role of hepatocyte nuclear factor 1alpha and 1beta in the transcriptional regulation of human dipeptidyl peptidase IV during differentiation of Caco-2 cells

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Identification of upstream stimulatory factor as an activator of the human dipeptidyl peptidase IV gene in Caco-2 cells

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Induction of the 2B9 antigen/dipeptidyl peptidase IV/CD26 on human natural killer cells by IL-2, IL-12 or IL-15.

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Dipeptidyl peptidase activity of CD26 in serum and urine as a marker of cholestasis: experimental and clinical evidence.

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A guardian angel: the involvement of dipeptidyl peptidase IV in psychoneuroendocrine function, nutrition and immune defence

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Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue

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Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer

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Absence of CD26 expression is a useful marker for diagnosis of T-cell lymphoma in peripheral blood

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Expression of CD26/dipeptidyl peptidase IV in adult T cell leukemia/lymphoma (ATLL).

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Constitutive expression of CD26/dipeptidylpeptidase IV on peripheral blood B lymphocytes of patients with B chronic lymphocytic leukaemia.

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Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis.

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T-cell immune parameters and depression in patients with Crohn's disease.

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Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease

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Eating disorders: a role for dipeptidyl peptidase IV in nutritional control

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Lowered serum dipeptidyl peptidase IV activity in patients with anorexia and bulimia nervosa.

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Decrease of serum dipeptidylpeptidase activity in severe sepsis patients: relationship to procalcitonin.

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Isolation and characterization of serum procalcitonin from patients with sepsis

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Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV).

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Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation.

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Natural substrates of dipeptidyl peptidase IV.

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CD26: a surface protease involved in T-cell activation

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Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides

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The structure and function of CD26 in the T-cell immune response

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Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.

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Processing of neuropeptide Y and somatostatin in human cerebrospinal fluid as monitored by radioimmunoassay and mass spectrometry

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A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36)

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Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion.

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Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium

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Autonomic regulation of islet hormone secretion--implications for health and disease

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Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding

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Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility

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Peptide YY (PYY)-immunoreactive neurons in the lower brain stem and spinal cord of rat.

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Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion

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PYY potently inhibits pancreatic exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG-stimulated pathways in awake rats

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Structure and receptor binding of PYY analogs.

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Liver dipeptidyl aminopeptidase IV hydrolyzes substance P

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Tachykinin receptors: a radioligand binding perspective.

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Studies of the enzymatic degradation of β-casomorphins

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Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV(EC 3.4.14.5) produces naloxone-reversible analgesia in rats

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Modulation of endomorphin-2-induced analgesia by dipeptidyl peptidase IV.

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Transbuccal peptide delivery: stability and in vitro permeation studies on endomorphin-1.

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Extreme stability of Tyr-MIF-1 in CSF.

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Growth hormone-releasing hormone

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Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation

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Structure-function relations in glucagon. Properties of highly purified Des-his1-, monoiodo-, and [Des-Asn28,Thr29](homoserine lactone27)-glucagon

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Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide

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Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist

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Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum

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Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs

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Biological actions and therapeutic potential of the glucagon-like peptides

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Gut adaptation and the glucagon-like peptides

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Therapeutic potential of the intestinotropic hormone, glucagon-like peptide-2.

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A Gastric Inhibitory Polypeptide II: The Complete Amino Acid Sequence

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Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain

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The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects

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Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcription

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Effects of gastric inhibitory polypeptide, vasoactive intestinal polypeptide and peptide histidine isoleucine on the secretion of hormones by isolated mouse pancreatic islets

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PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance.

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Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue

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Neuronal gastrin-releasing peptide in the mammalian gut and pancreas.

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Location and characterization of the human GRP receptor expressed by gastrointestinal epithelial cells

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The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter

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Interaction of bombesin and related peptides with receptors on pancreatic acinar cells

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Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion

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Direct cytoplasmic CA(2+) responses to gastrin-releasing peptide in single beta cells

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Gastrin-releasing peptide is a potent vasodilator in humans.

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Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2*

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Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients

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Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs

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Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients

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Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure

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Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients

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GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion

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Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.

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Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1.

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Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

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Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice.

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Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide

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Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective

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Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective".

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Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs

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NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

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Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide

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Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

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An active-site mutation (Gly633-->Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum

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The enteroinsular axis in dipeptidyl peptidase IV-negative rats

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Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats

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Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

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Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats

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Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats

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Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

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Dipeptidyl-peptidase IV/CD26 on T cells: analysis of an alternative T-cell activation pathway

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Molecular analysis of CD26-mediated signal transduction in T cells

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CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO.

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The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity

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Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells

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Unchanged signaling capacity of mutant CD26/dipeptidylpeptidase IV molecules devoid of enzymatic activity.

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Enhancement of antigen-induced T-cell proliferation by soluble CD26/dipeptidyl peptidase IV.

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Potentiation of the immune response in HIV-1+ individuals

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Soluble CD26/dipeptidyl peptidase IV induces T cell proliferation through CD86 up-regulation on APCs

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Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function

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Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes

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Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA.

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The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis

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Chemokines and leukocyte traffic

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Chemokines: a new classification system and their role in immunity

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Chemokines in pathology and medicine

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Chemokines: immunology's high impact factors

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Inhibition of HIV-1 Infection by the β-Chemokine MDC

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Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor.

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Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

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Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts

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The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine

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Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo

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Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

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CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity.

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Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes

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Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.

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Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4.

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Immunobiology of vasoactive intestinal peptide (VIP)

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VIP and PACAP38 modulate cytokine and nitric oxide production in peritoneal macrophages and macrophage cell lines

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Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP).

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Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype

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Involvement of dipeptidyl peptidase IV in an in vivo immune response

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Anti-arthritic effects of the novel dipeptidyl peptidase IV inhibitors TMC-2A and TSL-225.

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Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo

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Dipeptidyl amino peptidase IV cytochemistry in circulating lymphocytes from HIV-I-seropositive subjects

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T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

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CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

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Identification of a major co-receptor for primary isolates of HIV-1

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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

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The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

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The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

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gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules

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CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV–1 strains in a T–cell line

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Increased rate of HIV-1 entry and its cytopathic effect in CD4+/CXCR4+ T cells expressing relatively high levels of CD26.

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Negative regulation of the anti-human immunodeficiency virus and chemotactic activity of human stromal cell-derived factor 1alpha by CD26/dipeptidyl peptidase IV.

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The role of chemokines in human immunodeficiency virus infection

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Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesis

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Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands

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Inhibition of human immunodeficiency virus type 1 infection in a T-cell line (CEM) by new dipeptidyl-peptidase IV (CD26) inhibitors

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Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

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Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

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LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity

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Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils

21 January 2018

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Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage.

21 January 2018

1 reference

Processing by CD26/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1alpha

21 January 2018

1 reference

Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction

21 January 2018

1 reference

The adenosine deaminase-binding region is distinct from major anti-CD26 mAb epitopes on the human dipeptidyl peptidase IV(CD26) molecule

21 January 2018

1 reference

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

21 January 2018

1 reference

Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells

21 January 2018

1 reference

A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase

21 January 2018

1 reference

Dipeptidyl peptidase IV (DPPIV) inhibits cellular invasion of melanoma cells.

21 January 2018

1 reference

Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells

21 January 2018

1 reference

Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin

21 January 2018

1 reference

Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer?

21 January 2018

1 reference

Pitfalls in the light microscopical detection of NADH oxidase

21 January 2018

1 reference

A Fischer rat substrain deficient in dipeptidyl peptidase IV activity makes normal steady-state RNA levels and an altered protein. Use as a liver-cell transplantation model

21 January 2018

1 reference

Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities?

21 January 2018

1 reference

Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases.

21 January 2018

1 reference

1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties

21 January 2018

1 reference

Inhibition of dipeptidyl peptidase IV by fluoroolefin-containing N-peptidyl-O-hydroxylamine peptidomimetics

21 January 2018

1 reference

Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs

21 January 2018

1 reference

Specific and irreversible cyclopeptide inhibitors of dipeptidyl peptidase IV activity of the T-cell activation antigen CD26.

21 January 2018

1 reference

Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma

21 January 2018

1 reference

Substance P in human plasma is degraded by dipeptidyl peptidase IV, not by cholinesterase

21 January 2018

1 reference

Presence and release of SR-17 (chromogranin B(586-602)) in the porcine splenic nerve and its enzymatic degradation by CD26/dipeptidyl peptidase IV.

21 January 2018

1 reference

Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV.

21 January 2018

1 reference

Successive cleavage of N-terminal Arg1--Pro2 and Lys3-Pro4 from substance P but no release of Arg1-Pro2 from bradykinin, by X-Pro dipeptidyl-aminopeptidase

21 January 2018

1 reference

Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity

21 January 2018

1 reference

Regulation of CD26/DPPIV gene expression by interferons and retinoic acid in tumor B cells

21 January 2018

1 reference

Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

21 January 2018

1 reference

A prediction of DPP IV/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma

21 January 2018

1 reference

Adenosine deaminase in rodent median eminence: detection by antibody to the mouse enzyme and co-localization with adenosine deaminase-complexing protein (CD26)

21 January 2018

1 reference

Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs

21 January 2018

1 reference

Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects

21 January 2018

1 reference

Glucagon-Like Peptide I Enhances the Insulinotropic Effect of Glibenclamide in NIDDM Patients and in the Perfused Rat Pancreas

21 January 2018

1 reference

Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats

21 January 2018

1 reference

Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

21 January 2018

1 reference

Development of potent and selective dipeptidyl peptidase II inhibitors

21 January 2018

1 reference