Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium (Q35179335)

7 August 2017

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title

Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium (English)

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7 August 2017

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Michelle A Vincent

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7 August 2017

Monica Montagnani

series ordinal

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7 August 2017

Michael J Quon

series ordinal

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7 August 2017

publication date

1 August 2003

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7 August 2017

published in

Current diabetes report

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

279-288

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Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

7 August 2017

cites work

1 reference

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Insulin stimulates both endothelin and nitric oxide activity in the human forearm.

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Effects of sympathectomy and nitric oxide synthase inhibition on vascular actions of insulin in humans.

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Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

21 January 2018

1 reference

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Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase

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Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

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Hemodynamic actions of insulin

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Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

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Hemodynamic Actions of Insulin in Rat Skeletal Muscle: Evidence for Capillary Recruitment

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Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes.

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Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells

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Cerivastatin improves insulin sensitivity and insulin secretion in early-state obese type 2 diabetes.

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Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm.

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Synthesis and function of 3-phosphorylated inositol lipids

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Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release

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Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism

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The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

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Reversible insulin resistance in non-insulin-dependent diabetes mellitus

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Nitric oxide release accounts for insulin's vascular effects in humans

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Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans

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Improved endothelial function with metformin in type 2 diabetes mellitus

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Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance

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Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow

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Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells

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Effect of flow rate and glucose concentration on glucose uptake rate by the rat limb

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12 December 2020

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment

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Effects of insulin on vascular tone and sympathetic nervous system in NIDDM

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Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hindlimb

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Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM.

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Beta adrenergic-mediated vasodilator response to insulin in the human forearm.

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Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.

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Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

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Hypertension in mice lacking the gene for endothelial nitric oxide synthase

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Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension

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Cellular signaling: pivoting around PDK-1.

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Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

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Oxidative stress and insulin action: is there a relationship?

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Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

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The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

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Effect of perfusion rate on the time course of insulin-mediated skeletal muscle glucose uptake

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12 December 2020

Effect of exogenous insulin on blood pressure regulation in healthy and diabetic subjects.

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12 December 2020

Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.

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12 December 2020

Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells

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12 December 2020

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

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Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.

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Direct in vivo evidence of a vascular statin: a single dose of cerivastatin rapidly increases vascular endothelial responsiveness in healthy normocholesterolaemic subjects

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Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin

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Insulin signalling: metabolic pathways and mechanisms for specificity

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High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases

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12 December 2020

Mammalian nitric oxide synthases

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Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT 4 in skeletal muscles

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12 December 2020

Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats

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12 December 2020

Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells

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12 December 2020

Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound

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12 December 2020

Dilation of isolated skeletal muscle arterioles by insulin is endothelium dependent and nitric oxide mediated

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12 December 2020

Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo

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Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.

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PPARgamma and atherosclerosis: effects on cell growth and movement

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12 December 2020

Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway.

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12 December 2020

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

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12 December 2020

Endothelial dysfunction precedes hypertension in diet-induced insulin resistance.

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12 December 2020

Troglitazone, an insulin sensitizer, increases forearm blood flow in humans

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12 December 2020

10.1007/S11892-003-0018-9

Identifiers

DOI

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7 August 2017

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