Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. (Q35141261)

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3 February 2020

title

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis (English)

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3 February 2020

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3 February 2020

Fiona Powrie

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3 February 2020

Golnaz Vahedi

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3 February 2020

Haydeé L Ramos

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Wendy T Watford

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3 February 2020

Hayato Takahashi

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3 February 2020

Lydia Durant

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3 February 2020

Lai Wei

series ordinal

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3 February 2020

Hong-Wei Sun

series ordinal

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3 February 2020

John J O'Shea

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3 February 2020

language of work or name

English

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publication date

20 May 2010

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3 February 2020

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volume

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issue

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3 February 2020

page(s)

605-615

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The AP-1 transcription factor Batf controls T(H)17 differentiation

3 February 2020

cites work

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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

13 July 2018

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Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.

13 July 2018

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Control of regulatory T cell lineage commitment and maintenance

13 July 2018

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A protective function for interleukin 17A in T cell-mediated intestinal inflammation

13 July 2018

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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

13 July 2018

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Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

13 July 2018

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Homeostasis of naive and memory T cells

13 July 2018

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The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

13 July 2018

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IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

13 July 2018

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Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells

13 July 2018

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Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

13 July 2018

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

13 July 2018

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Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

13 July 2018

1 reference

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Induction and effector functions of T(H)17 cells.

13 July 2018

1 reference

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Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases

13 July 2018

1 reference

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Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

13 July 2018

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

13 July 2018

1 reference

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Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

13 July 2018

1 reference

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T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

13 July 2018

1 reference

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IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

13 July 2018

1 reference

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STAT3 mutations in the hyper-IgE syndrome

13 July 2018

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Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

13 July 2018

1 reference

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

13 July 2018

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Differentiation and function of Th17 T cells

13 July 2018

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Stat3 and Stat4 direct development of IL-17-secreting Th cells.

13 July 2018

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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

13 July 2018

1 reference

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Chromatin modifications and their function

13 July 2018

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Epigenetics: a landscape takes shape

13 July 2018

1 reference

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STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

13 July 2018

1 reference

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Nonredundant roles for Stat5a/b in directly regulating Foxp3

13 July 2018

1 reference

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IL-17 family cytokines and the expanding diversity of effector T cell lineages

13 July 2018

1 reference

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

13 July 2018

1 reference

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

13 July 2018

1 reference

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

13 July 2018

1 reference

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

13 July 2018

1 reference

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Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer

13 July 2018

1 reference

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Increased expression of interleukin 17 in inflammatory bowel disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element (IRE).

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148263

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes

8 December 2018

1 reference

12 December 2020

STAT3-mediated anti-inflammatory signalling

1 reference

12 December 2020

Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation

1 reference

12 December 2020

IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state

1 reference

12 December 2020

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

1 reference

12 December 2020

Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity

1 reference

12 December 2020

10.1016/J.IMMUNI.2010.05.003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20493732%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20493732%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

20493732

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20493732%20AND%20SRC:MED&resulttype=core&format=json