The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo (Q35128263)

6 August 2017

title

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo (English)

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6 August 2017

M J Grusby

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6 August 2017

K Kishimoto

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6 August 2017

V M Dong

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6 August 2017

S Issazadeh

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6 August 2017

E V Fedoseyeva

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6 August 2017

A M Waaga

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6 August 2017

A Yamada

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6 August 2017

M Sho

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6 August 2017

G Benichou

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6 August 2017

H Auchincloss

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6 August 2017

S J Khoury

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6 August 2017

M H Sayegh

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6 August 2017

language of work or name

English

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publication date

1 July 2000

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Journal of Clinical Investigation

6 August 2017

published in

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6 August 2017

volume

106

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6 August 2017

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6 August 2017

page(s)

63-72

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Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection

6 August 2017

cites work

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Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.

13 July 2018

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13 July 2018

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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection

13 July 2018

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

13 July 2018

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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

13 July 2018

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Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis

13 July 2018

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13 July 2018

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Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

13 July 2018

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New perspectives of CD28-B7-mediated T cell costimulation

13 July 2018

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CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

13 July 2018

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B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

13 July 2018

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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

13 July 2018

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Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway

13 July 2018

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A technique of cervical heterotopic heart transplantation in mice

13 July 2018

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Experimental graft arteriosclerosis. I. The Lewis-to-F-344 allograft model

13 July 2018

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Heart allografts in murine systems. The differential activation of Th2-like effector cells in peripheral tolerance

13 July 2018

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T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo

13 July 2018

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CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis.

13 July 2018

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Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice.

27 September 2018

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Cardiac allografts from IL-4 knockout recipients: assessment of transplant arteriosclerosis and peripheral tolerance.

27 September 2018

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The role of T-cell costimulatory activation pathways in transplant rejection

27 September 2018

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Cardiac allograft tolerance: failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns

27 September 2018

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Blockade of CD40-CD40 ligand pathway induces tolerance in murine contact hypersensitivity

27 September 2018

1 reference

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Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis

27 September 2018

1 reference

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Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

The role of CTLA-4 in regulating Th2 differentiation

27 September 2018

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Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

Chronic blockade of CD28-B7-mediated T-cell costimulation by CTLA4Ig reduces intimal thickening in MHC class I and II incompatible mouse heart allografts

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314364

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

27 September 2018

1 reference

12 December 2020

Evidence for epitope spreading and active suppression in skin graft tolerance after donor-specific transfusion

1 reference

12 December 2020

Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients

1 reference

12 December 2020

Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection

1 reference

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Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40

1 reference

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Mechanism of cyclosporin-induced tolerance to primarily vascularized allografts in miniature swine. Effect of administration of exogenous IL-2

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Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immunodeficient (SCID) mice

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Alloantigen-reactive Th1 development in IL-12-deficient mice

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Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy

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Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice

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Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

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The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts

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Identifiers

DOI

10.1172/JCI9586

1 reference

6 August 2017

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6 August 2017

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