The CD95(APO-1/Fas) DISC and beyond (Q35091401)

6 August 2017

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title

The CD95(APO-1/Fas) DISC and beyond (English)

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TRAIL death-inducing signaling complex

6 August 2017

main subject

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0031266

CD95 death-inducing signaling complex

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0031265

death-inducing signaling complex

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Gene Ontology release 2020-05-02

Peter ME

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6 August 2017

Krammer PH

series ordinal

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6 August 2017

language of work or name

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1 January 2003

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Cell Death & Differentiation

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

26-35

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Apoptosis signaling by death receptors.

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Caspase activation: the induced-proximity model

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Caspase-10 is an initiator caspase in death receptor signaling

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Inhibition of death receptor signals by cellular FLIP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Casper is a FADD- and caspase-related inducer of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

CASH, a novel caspase homologue with death effector domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The role of c-FLIP in modulation of CD95-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Activation of NF-kappaB by FADD, Casper, and caspase-8.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Tumor necrosis factor receptor and Fas signaling mechanisms.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Sequestration and inhibition of Daxx-mediated transcriptional repression by PML

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

PML is essential for multiple apoptotic pathways

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

1 reference

7 January 2021

FAP-1: a protein tyrosine phosphatase that associates with Fas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Negative regulation of Fas-mediated apoptosis by FAP-1 in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Down-regulation of Fas-associated phosphatase-1 (FAP-1) in interleukin-2-activated T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Apoptosis. Searching for FLASH domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Interaction of DAP3 and FADD only after cellular disruption

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Autoproteolytic activation of pro-caspases by oligomerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

An induced proximity model for caspase-8 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Dimer formation drives the activation of the cell death protease caspase 9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Inhibition of human caspases by peptide-based and macromolecular inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Signaling through protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Apoptosis through CD95 (Fas/APO-1), but not a CD40/CD95 chimeric receptor, is inhibited by phorbol-12-myristate-13-acetate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Inhibition of the protein kinase C pathway promotes anti-CD95-induced apoptosis in Jurkat T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Selective inhibition of protein kinase C isozymes by Fas ligation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

A physical interaction between the cell death protein Fas and the tyrosine kinase p59fynT.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

APO-1(CD95)-mediated apoptosis in Jurkat cells does not involve src kinases or CD45

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Ceramide enables fas to cap and kill.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

CD95 Signaling via Ceramide-rich Membrane Rafts

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Molecular ordering of the initial signaling events of CD95.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Potentiation of Fas-mediated apoptosis by an engineered glycosylphosphatidylinositol-linked Fas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Fas transduces activation signals in normal human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Caspase activation is required for T cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

T cell receptor-induced activation and apoptosis in cycling human T cells occur throughout the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Association of human fas (CD95) with a ubiquitin-conjugating enzyme (UBC-FAP)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401186

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401186

1 reference

Dimensions Publication ID

6 August 2017

1028177359

0 references

1 reference