Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease (Q35083891)

6 August 2017

title

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease (English)

1 reference

6 August 2017

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Inge Grundke-Iqbal

1 reference

6 August 2017

Hitoshi Tanimukai

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6 August 2017

Khalid Iqbal

series ordinal

1 reference

6 August 2017

language of work or name

English

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publication date

1 June 2005

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The American Journal of Pathology

6 August 2017

published in

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6 August 2017

volume

166

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6 August 2017

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6 August 2017

page(s)

1761-1771

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Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

6 August 2017

cites work

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Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

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PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

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Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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27 September 2018

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Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

27 September 2018

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Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.

27 September 2018

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27 September 2018

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

27 September 2018

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27 September 2018

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Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

27 September 2018

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Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

27 September 2018

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Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

27 September 2018

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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

27 September 2018

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Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney

27 September 2018

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Functional domains of template-activating factor-I as a protein phosphatase 2A inhibitor

7 January 2021

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Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

7 January 2021

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Identifiers

DOI

10.1016/S0002-9440(10)62486-8

1 reference

6 August 2017

1 reference

6 August 2017

1 reference