Molecular mechanisms of glucocorticoid action and resistance (Q35089953)

6 August 2017

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title

Molecular mechanisms of glucocorticoid action and resistance (English)

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6 August 2017

John A Cidlowski

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6 August 2017

Marcel J M Schaaf

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6 August 2017

publication date

1 December 2002

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The Journal of Steroid Biochemistry and Molecular Biology

6 August 2017

published in

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6 August 2017

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6 August 2017

issue

1-5

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6 August 2017

page(s)

37-48

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The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Characterization of the human glucocorticoid receptor promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

The human glucocorticoid receptor promoter upstream sequences contain binding sites for the ubiquitous transcription factor, Yin Yang 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Identification of human glucocorticoid receptor complementary DNA clones by epitope selection

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Functional domains of the human glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Molecular identification and characterization of a and b forms of the glucocorticoid receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Studies with Purified Chaperones Advance the Understanding of the Mechanism of Glucocorticoid Receptor-hsp90 Heterocomplex Assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Recent Advances in the Study of hsp90 Structure and Mechanism of Action

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Binding of hsp90 to the glucocorticoid receptor requires a specific 7-amino acid sequence at the amino terminus of the hormone-binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Structure/function of the human glucocorticoid receptor: tyrosine 735 is important for transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Valine 571 functions as a regional organizer in programming the glucocorticoid receptor for differential binding of glucocorticoids and mineralocorticoids

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Residues in the ligand binding domain that confer progestin or glucocorticoid specificity and modulate the receptor transactivation capacity.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Glucocorticoid receptor phosphorylation: overview, function and cell cycle-dependence.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Role of acidic and phosphorylated residues in gene activation by the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphoryl

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

DNA regulatory elements for steroid hormones

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Interaction of steroid hormone receptors with the transcription initiation complex

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Novel glucocorticoid receptor coactivator effector mechanisms

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Role of CBP/P300 in nuclear receptor signalling

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

p300 is a component of an estrogen receptor coactivator complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Glucocorticoid receptor-mediated chromatin remodeling in vivo.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Role of the negative glucocorticoid regulatory element in glucocorticoid repression of the human osteocalcin promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Inhibition of gene expression by steroid hormone receptors via a negative glucocorticoid response element: evidence for the involvement of DNA-binding and agonistic effects of the antiglucocorticoid/antiprogestin RU486.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Molecular mechanisms of glucocorticoid inhibition of human proopiomelanocortin gene transcription

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-kappa B and induction of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

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https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Regulation of Glucocorticoid Receptors by Glucocorticoids in Cultured HeLa S3Cells*

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Modulation of glucocorticoid receptors by mitogenic stimuli, glucocorticoids and retinoids in normal human cultured T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Stress down-regulates corticosterone receptors in a site-specific manner in the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Regulation of glucocorticoid receptors in brain by corticosterone treatment of adrenalectomized rats

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Regulation of the glucocorticoid receptor in human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in murine T-lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Human glucocorticoid receptor gene promotor-homologous down regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Autoregulation of glucocorticoid receptor gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Potential mechanisms underlying autoregulation of glucocorticoid receptor mRNA levels in the DHD/K12/PROb rat colonic adenocarcinoma cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

AU-rich elements: characterization and importance in mRNA degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

AUUUA motifs in the 3'UTR of human glucocorticoid receptor alpha and beta mRNA destabilize mRNA and decrease receptor protein expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Immunocytochemical analysis of the glucocorticoid receptor alpha isoform (GRalpha) using GRalpha-specific antibody.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Evidence That the β-Isoform of the Human Glucocorticoid Receptor Does Not Act as a Physiologically Significant Repressor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-kappaB: lack of effect of glucocorticoid receptor beta.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Natural variants of the beta isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Absence of Glucocorticoid Receptor-β in Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Low level of glucocorticoid receptor messenger ribonucleic acid in pituitary adenomas manifesting Cushing's disease with resistance to a high dose-dexamethasone suppression test.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Expression of the human glucocorticoid receptor alpha and beta isoforms in human respiratory epithelial cells and their regulation by dexamethasone.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Increased number of glucocorticoid receptor-beta-expressing cells in the airways in fatal asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Function and activation of NF-kappa B in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-0760%2802%2900263-7

7 January 2021

10.1016/S0960-0760(02)00263-7

Identifiers

DOI

1 reference

6 August 2017

1 reference