Nuclear receptors: integration of multiple signalling pathways through phosphorylation (Q35078424)

6 August 2017

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title

Nuclear receptors: integration of multiple signalling pathways through phosphorylation (English)

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6 August 2017

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Cécile Rochette-Egly

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6 August 2017

publication date

1 April 2003

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6 August 2017

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inferred from page(s)

published in

Cellular Signalling

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

355-366

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Nuclear receptors in cell life and death.

6 August 2017

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The promise of retinoids to fight against cancer.

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Formation of the androgen receptor transcription complex

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Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription.

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Importance of the regulation of nuclear receptor degradation

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The nuclear receptor ligand-binding domain: structure and function

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A canonical structure for the ligand-binding domain of nuclear receptors

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Three-dimensional models of estrogen receptor ligand binding domain complexes, based on related crystal structures and mutational and structure-activity relationship data.

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7 January 2021

Molecular basis of agonism and antagonism in the oestrogen receptor

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Atomic structure of progesterone complexed with its receptor

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Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

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7 January 2021

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

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Combinatorial control of gene expression by nuclear receptors and coregulators

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Steroid/nuclear receptor coactivators

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Cooperation between complexes that regulate chromatin structure and transcription

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Histone acetyltransferases

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Histone methylation in transcriptional control

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7 January 2021

Regulation of transcription by a protein methyltransferase

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Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities

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Snf1--a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription.

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7 January 2021

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

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The RNA polymerase II machinery: structure illuminates function

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Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

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7 January 2021

Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2.

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7 January 2021

p300 Mediates Functional Synergism between AF-1 and AF-2 of Estrogen Receptor α and β by Interacting Directly with the N-terminal A/B Domains

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7 January 2021

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins

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7 January 2021

p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively

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7 January 2021

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements

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7 January 2021

Structural determinants of nuclear receptor assembly on DNA direct repeats

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7 January 2021

The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

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7 January 2021

The nuclear receptor superfamily: the second decade

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7 January 2021

Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators

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7 January 2021

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

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7 January 2021

Principles of CDK regulation

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7 January 2021

Cyclin-dependent kinases: engines, clocks, and microprocessors

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7 January 2021

Mammalian MAP kinase signalling cascades

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7 January 2021

Steroid hormone receptors and their regulation by phosphorylation

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7 January 2021

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome

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7 January 2021

Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294.

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7 January 2021

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

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7 January 2021

Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1

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7 January 2021

The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway

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7 January 2021

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

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7 January 2021

Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma

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7 January 2021

Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain

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7 January 2021

Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2.

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7 January 2021

Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation

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7 January 2021

Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases

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7 January 2021

Stress pathway activation induces phosphorylation of retinoid X receptor

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7 January 2021

Mechanism of activation and function of protein kinase B.

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7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

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7 January 2021

PKB/AKT: functional insights from genetic models

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

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7 January 2021

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

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7 January 2021

Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization

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7 January 2021

Serine 157, a retinoic acid receptor alpha residue phosphorylated by protein kinase C in vitro, is involved in RXR.RARalpha heterodimerization and transcriptional activity

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7 January 2021

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function

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7 January 2021

Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex

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7 January 2021

Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7

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7 January 2021

TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7

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7 January 2021

From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator

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7 January 2021

The 14th Datta Lecture. TFIIH: from transcription to clinic

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7 January 2021

XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha

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7 January 2021

Phosphorylation of activation functions AF-1 and AF-2 of RARalpha and RARgamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment

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7 January 2021

The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells

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7 January 2021

A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA

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7 January 2021

Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha

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7 January 2021

p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response

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7 January 2021

The multifaceted mechanisms of estradiol and estrogen receptor signaling.

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7 January 2021

Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway

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7 January 2021

Emerging roles of ubiquitin in transcription regulation

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7 January 2021

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

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7 January 2021

Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase

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7 January 2021

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase

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7 January 2021

Transcriptional activation: risky business

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7 January 2021

Estradiol-binding mechanism and binding capacity of the human estrogen receptor is regulated by tyrosine phosphorylation.

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7 January 2021

Phosphorylation on Tyrosine ofin VitroSynthesized Human Estrogen Receptor Activates Its Hormone Binding

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7 January 2021

Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.

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7 January 2021

Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity

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7 January 2021

Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor

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7 January 2021

AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor

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7 January 2021

CREB-binding protein and p300 in transcriptional regulation

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7 January 2021

Phosphorylation of p300 at serine 89 by protein kinase C

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7 January 2021

The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export

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7 January 2021

Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM.

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7 January 2021

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

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7 January 2021

Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site

1 reference

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7 January 2021

c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity

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7 January 2021

Interdomain communication regulating ligand binding by PPAR-gamma

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7 January 2021

Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes

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7 January 2021

Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.

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7 January 2021

Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha

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7 January 2021

Oncogenic kinase signalling

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7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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7 January 2021

Akt takes centre stage in cell-cycle deregulation

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7 January 2021

The development of androgen-independent prostate cancer

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7 January 2021

Steroid-independent activation of androgen receptor in androgen-independent prostate cancer: a possible role for the MAP kinase signal transduction pathway?

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7 January 2021

Phosphoserine/threonine-binding domains

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7 January 2021

Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity

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7 January 2021

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

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7 January 2021

Acetylation: a regulatory modification to rival phosphorylation?

1 reference

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7 January 2021

Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.

1 reference

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7 January 2021

Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites

1 reference

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7 January 2021

Identification of a novel phosphorylation site in human androgen receptor by mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900115-8

7 January 2021

Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor

1 reference

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7 January 2021

Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900115-8

7 January 2021

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900115-8

7 January 2021

pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900115-8

7 January 2021

Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin

1 reference

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7 January 2021

10.1016/S0898-6568(02)00115-8

Identifiers

DOI

1 reference

6 August 2017

1 reference